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Review
. 2023 Jul 18;11(7):623.
doi: 10.3390/toxics11070623.

Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis

Christelle Oltramare  1 , Zakia Mediouni  1 , Yara Shoman  1 , Nancy B Hopf  1 , Halshka Graczyk  2 , Aurélie Berthet  1
Affiliations
Review

Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis

Christelle Oltramare et al. Toxics. .

Abstract

Few epidemiological studies use exposure determinants specifically tailored to assess pesticide or plant protection product (PPP) exposures when assessing presumed association between occupational exposure and health outcomes among agricultural workers. This lack of exposure specificity could lead to results that fail to detect an association. It could be related to the lack of consensus on exposure assessment methods and the choice of exposure determinants. We conducted a meta-analysis following the PRISMA checklist to identify PPP exposure determinants used in occupational studies and identified exposure determinants that best characterized agricultural exposures to PPPs. Out of 1436 studies identified, 71 were included. The exposure determinants identified were active ingredients, chemical classes, types of PPP, crops, tasks, frequencies, duration, lifetime exposure days, and intensity-weighted exposure days. Only six over 17 associations between exposure determinants and health outcomes were found with moderate quality of evidence. Overall, epidemiological studies had difficulty defining relevant determinants to characterize PPP exposures for agricultural workers. We recommend that a standardized list of determinants for PPP exposures in occupational exposure studies should include information on formulations, intensity, duration, and frequency of PPP exposure. Harmonized data collection on exposure and health outcomes are required as well as standard units for each exposure determinant.

Keywords: determinant of exposure; occupational exposure; pesticides.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA 2020 flow chart of publication selection.
See this image and copyright information in PMC

References

    1. World Health Organization . WHO Patient Safety Conceptual Framework for the International Classification for Patient Safety Version 1.1: Final Technical Report January 2009. World Health Organization; Geneva, Switzerland: 2010. p. 154.
    1. Dosemeci M., Alavanja M.C.R., Rowland A.S., Mage D., Zahm S.H., Rothman N., Lubin J.H., Hoppin J.A., Sandler D.P., Blair A. A Quantitative Approach for Estimating Exposure to Pesticides in the Agricultural Health Study. Ann. Occup. Hyg. 2002;46:245–260. doi: 10.1093/annhyg/mef011. - DOI - PubMed
    1. Mandić-Rajčević S., Rubino F.M., Colosio C. Exposure and Risk Assessment of Pesticide Use in Agriculture. Elsevier; Amsterdam, The Netherlands: 2021. Exposure and Risk Profiles: From Field Studies to Typical Exposure and Risk Scenarios; pp. 199–224.
    1. EFSA, (European Food Safety Authority) Guidance on the assessment of exposure of operators, workers, residents and bystanders in risk assessment for plant protection products|Autorité européenne de sécurité des aliments. Wiley Online Libr. 2014;12:3874. doi: 10.2903/j.efsa.2014.3874. - DOI
    1. Mostafalou S., Abdollahi M. Pesticides: An Update of Human Exposure and Toxicity. Arch. Toxicol. 2017;91:549–599. doi: 10.1007/s00204-016-1849-x. - DOI - PubMed

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