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Review
. 2023 Sep 1:93:129411.
doi: 10.1016/j.bmcl.2023.129411. Epub 2023 Jul 26.

A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation

Claudiu T Supuran  1
Affiliations
Review

A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation

Claudiu T Supuran. Bioorg Med Chem Lett. .

Abstract

Advances in the carbonic anhydrase (CA, EC 4.2.1.1) research over the last three decades are presented, with an emphasis on the deciphering of the activation mechanism, the development of isoform-selective inhibitors/ activators by the tail approach and their applications in the management of obesity, hypoxic tumors, neurological conditions, and as antiinfectives.

Keywords: Activator; Anticancer agent; Antiinfectives; Antiobesity drug; Carbonic anhydrase; Cognitive disorders; Coumarin; Drug design; Inhibition/activation mechanisms; Inhibitor; SLC-0111; Sulfonamide.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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