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Review
. 2023 Jul 11;13(14):2269.
doi: 10.3390/ani13142269.

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus NSP7 Protein

Huawei Li  1 , Qin Luo  2 , Huiyuan Jing  3 , Yuzhen Song  3 , Weili Kong  4 , Mengmeng Zhao  2 , Qingge Zhu  2
Affiliations
Review

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus NSP7 Protein

Huawei Li et al. Animals (Basel). .

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and severe infectious disease caused by the PRRS virus (PRRSV). PRRS is characterized by reproductive disorders in sows and respiratory dysfunction in pigs. Non-structural protein 7 (NSP7) is one of the most conserved functional proteins in PRRSV, and it plays an important role in viral replication and humoral immune responses in infected hosts. This review discusses the biological characteristics of NSP7 to provide theoretical support for its application in PRRS diagnosis, novel vaccine design, and therapeutic drug development.

Keywords: NSP7; PRRS; PRRSV; biological characteristics; research progress.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
PRRSV NSP7 interactions with host and viral proteins. NSP5 has an indirect interaction with NSP9 through NSP7α, and the L69 and F72 amino acid residues of NSP7α play an important role in this process. NSP7 can interact with NSP9 and NSP12 to form an RTC. NSP7 can interact with host RBM39 protein to promote PRRSV proliferation by down-regulating IFN-β production. NSP7 inhibits IFN and ISGs expression by down-regulating IRF7 expression.
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