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Review
. 2023 Jul 12;15(14):3583.
doi: 10.3390/cancers15143583.

Current Landscape of Genome-Wide Association Studies in Acute Myeloid Leukemia: A Review

Richard J Marrero  1 , Jatinder K Lamba  1   2   3
Affiliations
Review

Current Landscape of Genome-Wide Association Studies in Acute Myeloid Leukemia: A Review

Richard J Marrero et al. Cancers (Basel). .

Abstract

Acute myeloid leukemia (AML) is a clonal hematopoietic disease that arises from chromosomal and genetic aberrations in myeloid precursor cells. AML is one of the most common types of acute leukemia in adults; however, it is relatively rare overall, comprising about 1% of all cancers. In the last decade or so, numerous genome-wide association studies (GWAS) have been conducted to screen between hundreds of thousands and millions of variants across many human genomes to discover genetic polymorphisms associated with a particular disease or phenotype. In oncology, GWAS has been performed in almost every commonly occurring cancer. Despite the increasing number of studies published regarding other malignancies, there is a paucity of GWAS studies for AML. In this review article, we will summarize the current status of GWAS in AML.

Keywords: SNP; acute myeloid leukemia; genomics; pharmacogenetics; pharmacogenomics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Graphical summary based on chromosomal location of single nucleotide polymorphisms associated with risks or clinical outcomes, as reported in GWAS studies.
See this image and copyright information in PMC

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