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Review
. 2023 Jul 14;11(7):1995.
doi: 10.3390/biomedicines11071995.

Cell Adhesion Molecules in Fibrotic Diseases

Qianjiang Hu  1 , Komal Saleem  2 , Jyotsana Pandey  2 , Arzoo N Charania  2 , Yong Zhou  2 , Chao He  2
Affiliations
Review

Cell Adhesion Molecules in Fibrotic Diseases

Qianjiang Hu et al. Biomedicines. .

Abstract

Mechanisms underlying the pathogenesis of tissue fibrosis remain incompletely understood. Emerging evidence suggests that cell adhesion molecules (CAMs) are critical in fibrotic progression in many organs, including lung, kidney, skin, and liver. CAMs promote cell-cell and cell-extracellular matrix (ECM) interactions to maintain tissue architecture and normal function in homeostasis. However, dysregulated expression and function of CAMs can lead to chronic inflammation and tissue fibrosis. The major families of CAMs include integrins, cadherins, selectins, and immunoglobulins. Here, we review the role of the CAMs in fibrosis development across various organs with a focus on integrins and cadherins, and discuss their respective roles in the development of pulmonary fibrosis.

Keywords: cadherin; cell adhesion molecules; cirrhosis; extracellular matrix; integrin; pulmonary fibrosis.

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Conflict of interest statement

The authors declare no conflict of interest in this work.

Figures

Figure 1
Figure 1
CAMs in fibrosis. (A) Integrin binds to latent TGF-b complex and releases active TGF-b. (B) The homophilic interaction between cadherin-11 on macrophages and fibroblasts. (C) E-cadherin–catenin complex. The figure was created with BioRender.com.
See this image and copyright information in PMC

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