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Review
. 2023 Jul 20;11(7):2047.
doi: 10.3390/biomedicines11072047.

Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges

Qi Liu  1   2 , Yuan Gao  1   2 , Jinzhi He  1   2
Affiliations
Review

Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges

Qi Liu et al. Biomedicines. .

Abstract

Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth. To this end, stem cell-based regenerative endodontic treatment has been regarded as one of the most promising strategies for treating young permanent teeth with pulp and periapical infections. Endogenous stem cells residing in the apical papilla, named stem cells from the apical papilla (SCAPs), have been intensively investigated due to their critical roles in pulp regeneration and root redevelopment. The present review summarizes advances in the field of SCAPs studies and discusses the challenges that need to be further addressed.

Keywords: mesenchymal stem cells; regenerative endodontic treatment; stem cells from apical papilla.

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Conflict of interest statement

The authors declare no conflict of interest.

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