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. 2023 Jul 24;13(14):2461.
doi: 10.3390/diagnostics13142461.

Diagnostic Role of Native T1 Mapping Compared to Conventional Magnetic Resonance Techniques in Cardiac Disease in a Real-Life Cohort

Giovanni Donato Aquaro  1 , Silvia Monastero  2 , Giancarlo Todiere  3 , Andrea Barison  3 , Carmelo De Gori  3 , Crysanthos Grigoratos  3 , Maria Luisa Parisella  2 , Lorenzo Faggioni  2 , Dania Cioni  1 , Riccardo Lencioni  1 , Emanuele Neri  2
Affiliations

Diagnostic Role of Native T1 Mapping Compared to Conventional Magnetic Resonance Techniques in Cardiac Disease in a Real-Life Cohort

Giovanni Donato Aquaro et al. Diagnostics (Basel). .

Abstract

We sought to compare native T1 mapping to conventional late gadolinium enhancement (LGE) and T2-STIR techniques in a cohort of consecutive patients undergoing cardiac MRI (CMR). CMR was performed in 323 patients, 206 males (64%), mean age 54 ± 8 years, and in 27 age- and sex- matched healthy controls. In T2-STIR images, myocardial hyperintensity suggesting edema was found in 41 patients (27%). LGE images were positive in 206 patients (64%). T1 mapping was abnormal in 171 (49%). In 206 patients (64%), a matching between LGE and native T1 was found. T1 was abnormal in 32 out of 41 (78%) with edema in T2-STIR images. Overall, LGE and/or T2-STIR were abnormal in 209 patients, whereas native T1 was abnormal in 154 (52%). Conventional techniques and T1 mapping were concordant in 208 patients (64%). In 39 patients, T1 mapping was positive despite negative conventional techniques (12%). T1 mapping was able in conditions with diffuse myocardial damage such as cardiac amyloidosis, scleroderma, and Fabry disease (additive role in 42%). In contrast, T1 mapping was less effective in cardiac disease with regional distribution of myocardial damage such as myocardial infarction, HCM, and myocarditis. In conclusion, conventional LGE/T2-STIR and T1 mapping are complementary techniques and should be used together in every CMR examination.

Keywords: T1 mapping; T2-STIR; cardiac magnetic resonance; late gadolinium enhancement.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Concordance between conventional technique and T1 mapping in the whole population.
Figure 2
Figure 2
Concordance between conventional technique and T1 mapping in different subgroups.
Figure 3
Figure 3
Concordance between conventional technique and T1 mapping in different subgroups (DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy; ARVC, arrhythmogenic right ventricular cardiomyopathy).
Figure 4
Figure 4
A case of scleroderma with negative late gadolinium enhancement (LGE) and T2-weighted image (T2-STIR, short tau inversion recovery) but with a diffuse increase in myocardial native T1 (normal range of T1 in green).
Figure 5
Figure 5
A case of Fabry disease with mild concentric hypertrophy and low T1 (blue region) with negative conventional techniques.
See this image and copyright information in PMC

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