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. 2023 Jul 20;11(14):2071.
doi: 10.3390/healthcare11142071.

High Levels of Anxiety, Depression, Risk of Suicide, and Implications for Treatment in Patients with Lamellar Ichthyosis

Hernán Cortés  1 , Lizbeth Cariño-Calvo  2 , Octavio D Reyes-Hernández  3 , Martín Rojas-Márquez  4 , Jonathan J Magaña  1 , Pablo A Vizcaino-Dorado  1 , Edgar Y Villegas-Vazquez  5 , Laura Itzel Quintas-Granados  6 , Elizabeth Jiménez-Islas  7 , Valeria A Cortés-Mollinedo  8 , Gerardo Leyva-Gómez  7 , Manuel González-Del Carmen  8
Affiliations

High Levels of Anxiety, Depression, Risk of Suicide, and Implications for Treatment in Patients with Lamellar Ichthyosis

Hernán Cortés et al. Healthcare (Basel). .

Abstract

Lamellar ichthyosis (LI) is a genodermatosis that injures the structure and function of the skin, affecting the appearance and self-esteem of patients, which may seriously impair their mental health and quality of life. In the present study, we determined anxiety, depression, and suicidal risk levels in patients with LI through the Beck anxiety and depression inventories (BAI and DBI-II, respectively) and the SAD PERSONS scale (SPS). We observed that anxiety, depression, and suicidal ideation were strongly associated with the LI (Cramér's V = 0.429, 0.594, and 0.462, respectively). Furthermore, patients with LI showed a significant increase in the scores of anxiety, depression, and suicidal risk (p = 0.011, <0.001, and 0.001, respectively) compared to individuals without the disease. Additionally, the suicide risk increased even more in patients who presented comorbidity of anxiety and depression than in patients who presented only anxiety or depression (p = 0.02). Similarly, the increase in the BAI scores correlated with the score observed on the SPS. Our results indicate that patients with LI have higher levels of anxiety and depression compared to individuals without the disease, which could be associated with suicidal risk. Therefore, the collaborative involvement of skin and mental health professionals is necessary to manage patients with LI appropriately. We believe that psychiatric studies and individual evaluations must be performed in LI patients to determine a treatment that, in addition to reducing skin symptoms, focuses on reducing the levels of depression and anxiety and improving the quality of life to reduce the risk of suicide.

Keywords: anxiety; depression; lamellar ichthyosis; suicide risk.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Patients with lamellar ichthyosis. Brown scales are present in large zones of their body, including the face (a,c) and neck (b).
Figure 2
Figure 2
Correlation among BAI, DBI-II, and SPS scores in LI patients. (a) Correlation between the risk of suicide and anxiety scores. (b) Correlation between the risk of suicide and depression scores. rs = Spearman’s correlation coefficient.
See this image and copyright information in PMC

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References

    1. Vahlquist A., Gånemo A., Virtanen M. Congenital ichthyosis: An overview of current and emerging therapies. Acta Derm. Venereol. 2008;88:4–14. doi: 10.2340/00015555-0415. - DOI - PubMed
    1. Schmuth M., Gruber R., Elias P.M., Williams M.L. Ichthyosis update: Towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders. Adv. Dermatol. 2007;23:231–256. doi: 10.1016/j.yadr.2007.07.011. - DOI - PMC - PubMed
    1. González-Del Carmen M., Montaño S., Reyes-Hernández O.D., Vizcaíno-Dorado P.A., Leyva-García N., Morales-Morfín J.C., Diaz-Beltran W., Quinto-Santiago E., Msc L.C., Magaña J.J., et al. High prevalence of autosomal recessive congenital ichthyosis in a Mexican population caused by a new mutation in the TGM1 gene: Epidemiological evidence of a founder effect. Int. J. Dermatol. 2020;59:969–977. doi: 10.1111/ijd.14952. - DOI - PubMed
    1. Rodríguez-Pazos L., Ginarte M., Fachal L., Toribio J., Carracedo A., Vega A. Analysis of TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 in autosomal recessive congenital ichthyosis from Galicia (NW Spain): Evidence of founder effects. Br. J. Dermatol. 2011;165:906–911. doi: 10.1111/j.1365-2133.2011.10454.x. - DOI - PubMed
    1. Hernández-Martín A., Garcia-Doval I., Aranegui B., De Unamuno P., Rodríguez-Pazos L., González-Enseñat M.A., Vicente A., Martín-Santiago A., Garcia-Bravo B., Feito M., et al. Prevalence of autosomal recessive congenital ichthyosis: A population-based study using the capture-recapture method in Spain. J. Am. Acad. Dermatol. 2012;67:240–244. doi: 10.1016/j.jaad.2011.07.033. - DOI - PubMed

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