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. 2023 Jul 24;12(14):4862.
doi: 10.3390/jcm12144862.

Prevalence of Geographic Atrophy in Advanced Age-Related Macular Degeneration (AMD) in Daily Practice

Alaa Din Abdin  1 , Machteld Devenijn  2 , Roxana Fulga  2 , Achim Langenbucher  3 , Berthold Seitz  1 , Hakan Kaymak  2   3
Affiliations

Prevalence of Geographic Atrophy in Advanced Age-Related Macular Degeneration (AMD) in Daily Practice

Alaa Din Abdin et al. J Clin Med. .

Abstract

Purpose: To investigate the prevalence of geographic atrophy (GA) in advanced age-related macular degeneration (AMD) and the proportion of eyes that would meet the indication criteria for treatment with the first intravitreal anti-C3 agent (pegcetacoplan).

Methods: This retrospective cross-sectional study included all AMD patients who visited the Macular-Retina-Centre Oberkassel in 2021. Eyes were classified according to AMD stages. Eyes with GA were divided into two groups regarding foveal involvement. Baseline factors were compared between eyes with foveal GA (FGA) and eyes with non-foveal GA (NFGA) to identify predictive factors for foveal involvement.

Results: A total of 2033 eyes from 1027 patients were included. AMD stage was early in 296 (14.5%) cases, intermediate in 368 (18.1%) cases, and advanced in 1249 (61.4%) cases. A total of 1204 (60%) eyes had GA [932 (77%) FGA and 272 (23%) NFGA], while 125 eyes (27.4% from eyes with advanced dry AMD) met the indication criteria for treatment with intravitreal pegcetacoplan. The proportion of eyes with neovascular AMD was significantly higher in the FGA group compared to the NFGA group [598 (64.2%) vs. 152 (55.8%), p = 0.01].

Conclusions: At least a quarter of eyes with advanced AMD would be suitable for the upcoming intravitreal pegcetacoplan therapy. Foveal involvement of GA in advanced AMD seems to be more likely in neovascular AMD than in dry AMD.

Keywords: age-related macular degeneration; foveal involvement; geographic atrophy; intravitreal pegcetacoplan.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Geographic atrophy as detected by structural en face optical coherence tomography (Cirrus HD-OCT model 5000; Carl Zeiss Meditec AG, Jena, Germany).
Figure 2
Figure 2
The distribution of all study patients classified according to the different stages of age-related macular degeneration (AMD).
Figure 3
Figure 3
The distribution of eyes with foveal and non-foveal geographic atrophy (GA) classified according to the different types of advanced age-related macular degeneration (AMD).
See this image and copyright information in PMC

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