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. 2023 Jul 17;24(14):11549.
doi: 10.3390/ijms241411549.

Biochemical and Anthropometric Parameters for the Early Recognition of the Intrauterine Growth Restriction and Preterm Neonates at Risk of Impaired Neurodevelopment

Maria Cristina Aisa  1   2   3 , Benito Cappuccini  2 , Alessandro Favilli  1   2   3 , Alessandro Datti  4 , Vincenza Nardicchi  2 , Giuliana Coata  1   3 , Sandro Gerli  1   2   3
Affiliations

Biochemical and Anthropometric Parameters for the Early Recognition of the Intrauterine Growth Restriction and Preterm Neonates at Risk of Impaired Neurodevelopment

Maria Cristina Aisa et al. Int J Mol Sci. .

Abstract

Background: S100B and Tau are implicated with both brain growth and injury. Their urinary levels in 30-to-40-day-old full-term, preterm, IUGR, and preterm-IUGR subjects were measured to investigate their possible relationship with future delayed neurodevelopment.

Methods: Values were related to the neuro-behavioral outcome at two years of age, as well as to brain volumes and urinary NGF assessed at the same postnatal time point.

Results: Using the Griffiths III test, cognitive and motor performances were determined to establish subgroups characterized by either normal or impaired neuro-behavior. The latter included preterm, IUGR, and preterm-IUGR individuals who exhibited significantly higher and lower S100B and Tau levels, respectively, along with markedly reduced cerebral volumes and urinary NGF, as previously demonstrated. Contrary to NGF, however, Tau and S100B displayed a weak correlation with brain volumes.

Conclusions: Delayed cognitive and motor performances observed in two-year-old preterm and IUGR-born individuals were also found to be associated with anomalous urinary levels of S100B and Tau, assessed at 30-40 days of the postnatal period, and their changes did not correlate with brain growth. Thus, our data suggests that, in addition to cerebral volumes and NGF, urinary S100B and Tau can also be considered as valuable parameters for the early detection of future neurodevelopmental abnormalities.

Keywords: IUGR; NGF; S100B; Tau; cerebral volumes; impaired neurodevelopment; preterm.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Urinary S100B, Tau, and NGF in the normal and abnormal neurodevelopment subgroups.
Figure 2
Figure 2
Cerebral volumes in the normal and abnormal neurodevelopment subgroups. WBV: whole brain volume; TV: thalamus volume; FCV: frontal cortex volume; and CV: cerebellum volume.
Figure 3
Figure 3
Urinary S100B, Tau, and NGF in the normal and abnormal neurodevelopment subgroups with reference to neonates’ categories.
Figure 4
Figure 4
Cerebral volumes in the normal and abnormal neurodevelopment subgroups with reference to neonates’ categories. WBV: whole brain volume; TV: thalamus volume; FCV: frontal cortex volume; and CV: cerebellum volume.
See this image and copyright information in PMC

References

    1. Aisa M.C., Barbati A., Cappuccini B., Clerici G., Gerli S., Borisova A., De Rosa F., Kaptilnyy V.A., Ishenko A.I., Renzo G.C.D. 3-D Echo Brain Volumes to Predict Neurodevelopmental Outcome in Infants: A Prospective Observational Follow-up Study. Ultrasound Med. Biol. 2021;47:2220–2232. doi: 10.1016/j.ultrasmedbio.2021.03.029. - DOI - PubMed
    1. Aisa M.C., Barbati A., Gerli S., Clerici G., Nikolova N., Giardina I., Babucci G., De Rosa F., Cappuccini B. Brain 3D-echographic early predictors of neuro-behavioral disorders in infants: A prospective observational study. J. Matern. Fetal Neonatal Med. 2022;35:642–650. doi: 10.1080/14767058.2020.1730323. - DOI - PubMed
    1. Aisa M.C., Barbati A., Cappuccini B., De Rosa F., Gerli S., Clerici G., Kaptilnyy V.A., Ishenko A.I., Di Renzo G.C. Urinary Nerve Growth Factor in full-term, preterm and intra uterine growth restriction neonates: Association with brain growth at 30-40 days of postnatal period and with neuro-development outcome at two years. A pilot study. Neurosci. Lett. 2021;741:135459. doi: 10.1016/j.neulet.2020.135459. - DOI - PubMed
    1. Spittle A., Orton J., Boyd R. Early developmental intervention programs post hospital discharge to prevent motor and cognitive impairments in preterm infants. In: The Cochrane Collaboration, editor. The Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd.; Chichester, UK: 2005. p. CD005495. - PubMed
    1. McCormick M.C., Brooks-Gunn J., Buka S.L., Goldman J., Yu J., Salganik M., Scott D.T., Bennett F.C., Kay L.L., Bernbaum J.C., et al. Early Intervention in Low Birth Weight Premature Infants: Results at 18 Years of Age for the Infant Health and Development Program. Pediatrics. 2006;117:771–780. doi: 10.1542/peds.2005-1316. - DOI - PubMed

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