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. 2023 Jun 27;13(7):1053.
doi: 10.3390/jpm13071053.

Nocturia and Sleep in Parkinson's Disease

Ştefania Diaconu  1   2 , Laura Irincu  1   2 , Larisa Ungureanu  1   2 , Diana Țînț  2   3 , Cristian Falup-Pecurariu  1   2
Affiliations

Nocturia and Sleep in Parkinson's Disease

Ştefania Diaconu et al. J Pers Med. .

Abstract

Background: Nocturia has a high prevalence in Parkinson's Disease (PD) and is known to be a bothersome symptom for people with Parkinson's disease (PwPD).

Objective: to characterize nocturia in a sample of PwPD, in relation to sleep, fatigue and other non-motor symptoms (NMS).

Methods: we assessed 130 PwPD using a comprehensive battery of scales, which includes the Non-Motor Symptoms Questionnaire (NMSQ), International Parkinson and Movement Disorder Society Non-Motor Rating Scale (MDS-NMS), Parkinson's Disease Sleep Scale version 2 (PDSS-2), Parkinson's Disease Questionnaire (PDQ-39), The Overactive Bladder Questionnaire-Short form (OABq-SF), and the Parkinson's Fatigue Scale (PFS-16).

Results: according to the positive answers to the item of the NMSQ related to nocturia, patients were divided into PwPD + nocturia, and PwPD - nocturia. Nocturia was reported by 112 patients (86.15%). Quality of life in PwPD + nocturia was worse than in PwPD - nocturia, according to the PDQ-39 scores (13.32 ± 9.00 vs. 26.29 ± 14.55, p < 0.001). Sleep was significantly disturbed in PwPD + nocturia compared to PwPD - nocturia, according to the total scores of various scales, such as PDSS-2, PFS-16. PwPD who complained of nocturia presented higher scores of several NMS.

Conclusions: nocturia has a high prevalence in PwPD and it is associated with impaired sleep, fatigue, and reduced quality of life.

Keywords: Parkinson’s disease; fatigue; nocturia; non-motor symptoms; sleep dysfunctions; urinary tract dysfunctions.

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Conflict of interest statement

C.F.-P. received royalties from Elsevier and Springer Verlag, honoraria from Abbvie and the International Parkinson’s Disease and Movement Disorders Society, outside of the present work. D.T. received honoraria from Pfizer, Boehringer Ingelheim, Bayer, Novartis, and Astra Zeneca outside of the present work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The last author is currently co-Editor of the Special Issue.

Figures

Figure 1
Figure 1
PDSS-2 scores of individual items in PwPD + nocturia vs. PwPD − nocturia. Significant differences were marked with asterisk (*). PDSS-2: Parkinson Disease Sleep Scale-2; PwPD: people with Parkinson’s disease.
See this image and copyright information in PMC

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