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Case Reports
. 2023 Jul 9;59(7):1274.
doi: 10.3390/medicina59071274.

Hemophagocytic Lymphohistiocytosis Secondary to Hodgkin's Lymphoma with Isolated Bone Marrow Involvement in a Newly Diagnosed HIV Patient

Alberto Lopez-Garcia  1   2 , Laura Solan  1   2 , Beatriz Alvarez  3 , Juan Carlos Caballero  1 , Javier Cornago  1 , Laura Pardo  1 , Francisco Javier Diaz de la Pinta  4 , Raul Cordoba  1   2 , Maria Rodriguez-Pinilla  2   4
Affiliations
Case Reports

Hemophagocytic Lymphohistiocytosis Secondary to Hodgkin's Lymphoma with Isolated Bone Marrow Involvement in a Newly Diagnosed HIV Patient

Alberto Lopez-Garcia et al. Medicina (Kaunas). .

Abstract

Human immunodeficiency virus (HIV) infection is known to be associated with the development of Hodgkin's lymphoma (HL). Exclusive extranodal bone marrow involvement is less common. Co-infection by other viruses, such as the Epstein-Barr virus (EBV), increases the incidence of a frequent complication denominated by hemophagocytic lymphohistocytosis (HLH). We present the case of a 50-year-old patient with the above clinical spectrum who develops several serious complications during treatment.

Keywords: Epstein–Barr virus; Hodgkin’s lymphoma; hemophagocytic lymphohistiocytosis; human immunodeficiency virus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Bone marrow biopsy. (A): Hematoxylin eosin stain × 40. (B): EBER in situ hybridization. (C): PAX5. (D): CD30.
Figure 2
Figure 2
PET-CT scan images. (A): The hepatic hilum lymphadenopathy is marked with arrows. (B): Inguinal lymphadenopathy. (C): Hepatomegaly. (D) Mesenteric lymphadenopathy.
Figure 3
Figure 3
Inguinal lymph node biopsy. Hematoxylin eosin stain × 40.
Figure 4
Figure 4
EBV viral copies after Rituximab initiation.
Figure 5
Figure 5
CMV ulcers. (A): Hematoxylin eosin stain × 40. Arrow-headed cell with owl’s eye appearance typical of CMV infection. (B): CMV.
See this image and copyright information in PMC

References

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