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. 2023 Jul 9;59(7):1278.
doi: 10.3390/medicina59071278.

Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus

Ya-Li Huang  1   2 , Yen-Lin Chen  3 , Jiunn-Diann Lin  4   5 , Dee Pei  6   7 , Pietro Pitrone  8 , Jin-Shuen Chen  9   10   11 , Chung-Ze Wu  4   5
Affiliations

Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus

Ya-Li Huang et al. Medicina (Kaunas). .

Abstract

Background and Objectives: The prevalence of type 2 diabetes mellitus in adolescents has increased rapidly in recent decades. However, the role of adipokines on pathophysiology in young-onset type 2 diabetes mellitus (YDM) is not clear. In this article, we explored the relationships between the adipokines (visfatin and retinol binding protein 4 (RBP4)) and metabolic syndrome (MetS) components in both YDM and late-onset type 2 diabetes mellitus (ODM). Materials and Methods: There were 36 patients with YDM (23.6 ± 4.8 years) and 36 patients with ODM (54.3 ± 10.1 years) enrolled. Visfatin, RBP4, and MetS components were measured. The relationships between visfatin, RBP4 and MetS components were assessed in YDM and ODM. Results: The visfatin, but not the RPB4 level, was significantly higher in YDM than in ODM. After adjusting for age and body mass index, visfatin was not related to any MetS components except that there was a negative correlation with fasting plasma glucose (FPG). As for RPB4, triglyceride was found to be positively and FPG negatively related to RBP4 in YDM. However, in ODM, the only positive relationship that existed was between RBP4 and diastolic blood pressure. Conclusions: In conclusion, both visfatin and RBP4 had certain roles in diabetes and MetS although their relationships were different in YDM and ODM. Further studies are needed to explore their physiological and pathological effects in glucose metabolism.

Keywords: metabolic syndrome; old diabetes mellitus; retinol binding protein 4; visfatin; young diabetes mellitus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flowchart of the process on patient selection.
Figure 2
Figure 2
The circulating (A) visfatin and (B) retinol binding protein 4 (RBP4) levels in subjects with young onset type 2 diabetes mellitus (YDM) and old diabetes mellitus (ODM). (A) Visfatin levels in YDM were significantly higher than those in ODM. (** p < 0.01). (B) RBP4 levels showed no significant difference between YDM and ODM.
See this image and copyright information in PMC

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