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. 2023 Jul 14;15(14):3139.
doi: 10.3390/nu15143139.

The Association of Surrogates of Insulin Resistance with Hyperuricemia among Middle-Aged and Older Individuals: A Population-Based Nationwide Cohort Study

Yutong Han  1   2 , Zonglei Zhou  1 , Yuge Zhang  1   2 , Genming Zhao  1   2 , Biao Xu  1   2
Affiliations

The Association of Surrogates of Insulin Resistance with Hyperuricemia among Middle-Aged and Older Individuals: A Population-Based Nationwide Cohort Study

Yutong Han et al. Nutrients. .

Abstract

The triglyceride-glucose (TyG) index, triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C) ratio, metabolic score for insulin resistance (METS-IR) and TyG with body mass index (TyG-BMI) have been proposed as indicators of insulin resistance (IR). This study aimed to explore the association between these IR surrogates and their longitudinal variation with the development of hyperuricemia in a middle-aged and older Chinese population. Data from the China Health and Retirement Longitudinal Study (CHARLS) was used to identify 5269 participants aged ≥45 years. Logistic regression was used to assess the effect of IR surrogates and their variations on the risk of hyperuricemia. After four years of follow-up, 517 (9.81%) participants developed incident hyperuricemia. Increased baseline values of TyG, TG/HDL, METS-IR, and TyG-BMI were all significantly associated with higher risks of hyperuricemia. Compared to individuals with maintained low levels of IR surrogates, those with low-to-high and maintained high variation patterns had a significantly higher risk of hyperuricemia. These four IR surrogates have comparable predictive ability for hyperuricemia. This study provides evidence of the associations between IR and hyperuricemia. Early intervention among middle-aged and elderly Chinese individuals with high IR levels may effectively reduce the burden of hyperuricemia.

Keywords: cohort study; hyperuricemia; insulin resistance.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart for selecting the study population from the database of CHARLS.
Figure 2
Figure 2
Receiver operating characteristic (ROC) curves for incident hyperuricemia comparing TyG, TG/HDL-C, TyG-BMI, and METS-IR.
Figure 3
Figure 3
The associations of (A) TyG index, (B) TG/HDL-C, (C) METS-IR, and (D) TyG-BMI at baseline with hyperuricemia in Chinese middle-aged population. Data were fitted by logistic regression models of the restricted cubic spline with 3 knots adjusting for age, sex, resident, education level, married status, smoking history, drinking history, hypertension, diabetes cardiovascular disease, dyslipidemia, total cholesterol, blood urea nitrogen, creatinine, glycated hemoglobin, and C-reactive protein.
See this image and copyright information in PMC

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