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Review
. 2023 Jul 13:13:1213273.
doi: 10.3389/fonc.2023.1213273. eCollection 2023.

Spatial metabolomics in head and neck tumors: a review

Ye Zheng  1   2 , Chen Lin  1   2 , Yidian Chu  1   2 , Shanshan Gu  2 , Hongxia Deng  2 , Zhisen Shen  1   2
Affiliations
Review

Spatial metabolomics in head and neck tumors: a review

Ye Zheng et al. Front Oncol. .

Abstract

The joint analysis of single-cell transcriptomics, proteomics, lipidomics, metabolomics and spatial metabolomics is continually transforming our understanding of the mechanisms of metabolic reprogramming in tumor cells. Since head and neck tumor is the sixth most common tumor in the world, the study of the metabolic mechanism of its occurrence, development and prognosis is still undeveloped. In the past decade, this field has witnessed tremendous technological revolutions and considerable development that enables major breakthroughs to be made in the study of human tumor metabolism. In this review, a comprehensive comparison of traditional metabolomics and spatial metabolomics has been concluded, and the recent progress and challenges of the application of spatial metabolomics combined multi-omics in the research of metabolic reprogramming in tumors are reviewed. Furthermore, we also highlight the advances of spatial metabolomics in the study of metabolic mechanisms of head and neck tumors, and provide an outlook of its application prospects.

Keywords: Spatial metabolomics; head and neck tumors; mass spectrometry imaging; metabolic reprogramming; tumor metabolism.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Manufacturing flow for the final spatial metabolic images from the tumor samples.
Figure 2
Figure 2
The process of transformation in multi-omics in the research of human tumor’s biology.
See this image and copyright information in PMC

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