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. 2023 Jul 13:15:1126587.
doi: 10.3389/fnagi.2023.1126587. eCollection 2023.

Dementia incidence and population-attributable fraction for dementia risk factors in Republic of Korea: a 12-year longitudinal follow-up study of a national cohort

Song Hwangbo #  1   2 , Jin Young Lee #  3 , Gyule Han  4 , Min Young Chun  5 , Hyemin Jang  1   6 , Sang Won Seo  1   2   6 , Duk L Na  1   2 , Sungho Won  7 , Hee Jin Kim  1   2   6 , Dong Hui Lim  4   8
Affiliations

Dementia incidence and population-attributable fraction for dementia risk factors in Republic of Korea: a 12-year longitudinal follow-up study of a national cohort

Song Hwangbo et al. Front Aging Neurosci. .

Abstract

Background: We aimed to investigate the incidence of dementia by age and year as well as the population-attributable fractions (PAFs) for known dementia risk factors in Republic of Korea.

Methods: A 12-year, nationwide, population-based, retrospective cohort study was conducted. We used customized health information from the National Health Insurance Service (NHIS) data from 2002 to 2017. We analyzed age- and sex-adjusted incidence rates and PAF of dementia for each risk factor such as depression, diabetes, hemorrhagic stroke, ischemic stroke, hypertension, osteoporosis and physical inactivity using Levin's formula.

Results: Of the 794,448 subjects in the dementia-free cohort, 49,524 (6.2%) developed dementia. Dementia incidence showed annual growth from 1.56 per 1,000 person-years in 2006 to 6.94 per 1,000 person-years in 2017. Of all dementia cases, 34,544 subjects (69.8%) were female and 2,479 subjects (5.0%) were early onset dementia. AD dementia accounted for 66.5% of the total dementia incidence. Considering relative risk and prevalence, physical inactivity attributed the greatest to dementia (PAF, 8.1%), followed by diabetes (PAF, 4.2%), and hypertension (PAF, 2.9%). Altogether, the significant risk factors increased the risk of dementia by 18.0% (overall PAF).

Conclusion: We provided the incidence of dementia and PAFs for dementia risk factors in Republic of Korea using a 12-year, nationwide cohort. Encouraging lifestyle modifications and more aggressive control of risk factors may effectively prevent dementia.

Keywords: Alzheimer’s disease dementia; dementia; national cohort; population-attributable fraction; risk factor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow chart of eligible subjects in the dementia-free cohort. *Diagnosis of dementia was based on both International Classification of Diseases-10 diagnosis codes (F00, F01, F02, F03, G30, or G31) and medication prescriptions (donepezil, galantamine, rivastigmine, or memantine).
FIGURE 2
FIGURE 2
Incidence rate of dementia in the South Korean population. Incidence rate of all-cause dementia (A) and Alzheimer’s disease (AD) dementia (B) by year. Incidence rate of all-cause dementia (C) and AD dementia (D) by age. Bars represent 95% confidence intervals.
See this image and copyright information in PMC

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