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Review
. 2023 Jul 26;10(7):ofad358.
doi: 10.1093/ofid/ofad358. eCollection 2023 Jul.

Mortality of Patients With Candidemia and COVID-19: A Systematic Review With Meta-analysis

Marta Colaneri  1   2 , Emanuele Maria Giusti  3 , Camilla Genovese  1   4 , Lucia Galli  1   4 , Andrea Lombardi  4   5 , Andrea Gori  1   2
Affiliations
Review

Mortality of Patients With Candidemia and COVID-19: A Systematic Review With Meta-analysis

Marta Colaneri et al. Open Forum Infect Dis. .

Abstract

Mortality of candidemia in coronavirus disease 2019 (COVID-19) patients has not been deeply studied despite evidence suggesting an increased occurrence. We performed a systematic review and meta-analysis to summarize the available evidence about these patients' mortality and length of stay. Data about the in-hospital, all-cause and 30-day mortality, and length of stay were pooled. Subgroup analyses were performed to assess sources of heterogeneity. Twenty-six articles out of the 1915 records retrieved during the search were included in this review. The pooled in-hospital mortality was 62.62% (95% CI, 54.77% to 69.86%), while the mortality in intensive care unit (ICU) was 66.77% (95% CI, 57.70% to 74.75%). The pooled median in-hospital length of stay was 30.41 (95% CI, 12.28 to 48.55) days, while the pooled median length of stay in the ICU was 28.28 (95% CI, 20.84 to 35.73) days. The subgroup analyses did not identify the sources of heterogeneity in any of the analyses. Our results showed high mortality in patients with candidemia and COVID-19, suggesting the need to consider screening measures to prevent this life-threatening condition.

Keywords: COVID-19; candidemia; meta-analysis; mortality; systematic review.

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Conflict of interest statement

Potential conflicts of interest. All authors: no reported conflicts.

Figures

Figure 1.
Figure 1.
Study selection chart. Abbreviation: COVID-19, coronavirus disease 2019.
Figure 2.
Figure 2.
Forest plot for in-hospital mortality.
Figure 3.
Figure 3.
Forest plot for in-ICU mortality. Abbreviation: ICU, intensive care unit.
See this image and copyright information in PMC

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