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. 2022;9(1):55.
doi: 10.1186/s40538-022-00325-z. Epub 2022 Aug 12.

Green synthesized silver nanoparticles using Cyperus rotundus L. extract as a potential antiviral agent against infectious laryngotracheitis and infectious bronchitis viruses in chickens

Zahraa Hamdi Abo-El-Yazid  1 , Osama Konsowa Ahmed  1 , Mohamed El-Tholoth  2   3 , Mohamed Abdel-Shakur Ali  1
Affiliations

Green synthesized silver nanoparticles using Cyperus rotundus L. extract as a potential antiviral agent against infectious laryngotracheitis and infectious bronchitis viruses in chickens

Zahraa Hamdi Abo-El-Yazid et al. Chem Biol Technol Agric. 2022.

Abstract

Background: Infectious laryngotracheitis (ILT) and infectious bronchitis (IB) are two common respiratory diseases of poultry that inflict great economic burden on the poultry industry. Developing an effective agent against both viruses is a crucial step to decrease the economic losses. Therefore, for the first time green synthesized silver nanoparticles using Cyperus rotundus L. aqueous extract was evaluated in vitro as a potential antiviral against both viruses.

Results: Silver nanoparticles from Cyperus rotundus were characterized by the spherical shape, 11-19 nm size, and zeta potential of - 6.04 mV. The maximum nontoxic concentration (MNTC) was 50 µg mL-1 for both viruses without harmful toxicity impact. The study suggested that some of the compounds in C. rotundus extract (gallic acid, chlorogenic acid, and naringenin) or its silver nanoparticles could interact with the external envelope proteins of both viruses, and inhibiting extracellular viruses.

Conclusions: The results highlight that C. rotundus green synthesized silver nanoparticles could have antiviral activity against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) in chickens.

Keywords: Antiviral activity; Avian coronavirus; Chickens; Cyperus rotundus; Infectious bronchitis virus; Infectious laryngotracheitis virus; Silver nanoparticles.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
UV–visible spectrum of Cyperus rotundus silver nanoparticles
Fig. 2
Fig. 2
Cyperus rotundus aqueous extract morphology change in color
Fig. 3
Fig. 3
Transmission electron microscope micrograph of Cyperus rotundus silver nanoparticles
Fig. 4
Fig. 4
Zeta potential (a) and DLS (b) of Cyperus rotundus SNPs
Fig. 5
Fig. 5
ATR-FT-IR spectrum of Cyperus rotundus silver nanoparticles
See this image and copyright information in PMC

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