Mind the gap: leak currents and induced pluripotent stem cell-derived cardiomyocytes in translational cardiac electrophysiology
- PMID: 37522360
- PMCID: PMC10445299
- DOI: 10.1093/europace/euad236
Mind the gap: leak currents and induced pluripotent stem cell-derived cardiomyocytes in translational cardiac electrophysiology
Abstract
Keywords: Cellular electrophysiology; Induced pluripotent stem cell–derived cardiomyocytes; Patch clamp; hiPSC.
Conflict of interest statement
Conflict of interest: None declared.
Comment on
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Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings.Europace. 2023 Aug 2;25(9):euad243. doi: 10.1093/europace/euad243. Europace. 2023. PMID: 37552789 Free PMC article.
References
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- Timmis A, Vardas P, Townsend N, Torbica A, Katus H, De Smedt Det al. . European Society of Cardiology: cardiovascular disease statistics 2021. Eur Heart J 2022;43:716–99. - PubMed
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