Dipeptidyl peptidase-4 inhibitors reduce the incidence of first cardiovascular events in Japanese diabetic patients

Collaborators, Affiliations

Collaborators

JPAD Trial Investigators:
Kimiaki Miwa, Kazunobu Akahoshi, Kenji Misumi, Haruo Araki, Yutaka Mitsudo, Norifumi Kondo, Kenichi Ashihara, Shinya Yumoto, Masashi Horimoto, Osamu Doi, Kenichi Doijiri, Ryo Fukami, Michio Shimabukuro, Genshi Egusa, Kazuo Goto, Yoichi Hanaoka, Yoshihiro Kimura, Yoshikuni Haraguchi, Osamu Haraguchi, Atsushi Hasegawa, Yoshiko Shioya, Yosuke Shioya, Eiitiro Tanaka, Kazuhiko Yamada, Toshiya Atsumi, Satoshi Tanazawa, Yutaka Horio, Seishi Ichihara, Isao Yasuda, Tsuneo Ikeda, Makoto Ikemura, Chieko Imamoto, Yoshihisa Iseri, Ken Iwai, Shinya Okamoto, Seigo Sugiyama, Masanori Kamura, Hirofumi Kan, Mayumi Kiyota, Kyousuke Kawamura, Takashi Ono, Takeshi Koga, Etsuo Kinuwaki, Hiromichi Naito, Kazuo Kozuma, Kiyotaka Kudou, Yasuhiro Morikami, Hirofumi Yasue, Yuji Mizuno, Hisao Fujimoto, Kozaburo Matsuyama, Hiromi Fujii, Syuichi Kamijikkoku, Tetsuo Kuwahara, Kyoji Takaoka, Kazuo Machii, Kazutaka Maeda, Keiji Mahara, Akira Maki, Naoki Manda, Kousuke Marutsuka, Naoki Sameshima, Toshihiro Gi, Terufumi Matsunaga, Syuichi Matsuo, Hiroto Okubo, Fuyuki Minagawa, Kotaro Minoda, Junichi Miyata, Takeshi Matsuo, Sueo Momosaki, Tetsuo Munakata, Tomoki Nakamura, Hisatoshi Nagano, Kazuto Goshi, Keisuke Sugimoto, Shojiro Naomi, Toshiaki Nasu, Hiroyuki Tanaka, Ryuji Sonoda, Keizo Kajiwara, Takafumi Odo, Hirofumi Ogata, Masayuki Ogihara, Tateo Ogura, Keishiro Oka, Eiji Kawashima, Eiji Oshima, Ken Ozaki, Seiji Ozawa, Hiroyuki Shono, Yasuhiro Sakamoto, Nobuko Sakurai, Chikashi Wakabayashi, Tomohiro Sawada, Junji Shibata, Hisashi Shimono, Akihiro Iemura, Akira Matsutani, Hisakazu Suefuji, Hiromichi Sugiyama, Jun Hokamaki, Kenichi Komori, Yoshimi Kinoshita, Hironori Murakami, Jun Hashiguchi, Yasuhiro Hashiguchi, Koryo Sawai, Atuko Hifumi, Koji Seo, Masamitsu Toihata, Koji Tokube, Hiroshi Ogawa, Fumishi Tomita, Madoka Taguchi, Toshio Tsubokura, Tatsuaki Tsuchiya, Kaoru Tsuda, Ryuichiro Tsurusaki, Kenji Obata, Katumi Watanabe, Raisuke Hayasida, Yutaka Ishibashi, Yoshiaki Osamura, Yoshito Yamanaka, Kazuhiro Sonoda, Taisuke Iwaoka, Hiromitsu Yokota, Motoki Yoshinari, Nanami Abe, Noriaki Ando, Hiroshi Bando, Takeshi Takami, Michiaki Doi, Yoshihiro Fujii, Masahiro Fukuda, Yoshiaki Fukuoka, Masayoshi Hamano, Minoru Takaoka, Hiromi Hasegawa, Ikuo Yabuta, Kenshi Higami, Satomi Higami, Akiko Yasuno, Yuriko Fujinaga, Yoko Onishi, Katsutoshi Yoshimura, Shigetoshi Minami, Takao Nakashima, Hiroaki Horie, Kazuko Horii, Norihiko Matsumura, Tetsuo Ikuno, Yoshiyuki Katsuyama, Shiro Uemura, Masao Kikukawa, Masao Kanauchi, Hideshi Kuzuya, Arata Iwasaki, Takehiko Koutani, Hisaharu Makino, Hiroshi Miki, Susumu Misugi, Masaki Naito, Masatoshi Naito, Yukitaka Nakano, Akira Nakatani, Fumihiko Nakatani, Manabu Horii, Matahiro Yabuta, Ayako Seno, Hiroyuki Kawata, Kenichi Samejima, Kenji Onoue, Rika Kawakami, Tomoya Nakano, Tomoya Ueda, Tsunenari Soeda, Yoko Kita, Fumitaka Inoue, Shigeru Yamano, Hajime Iwama, Hirokazu Sakan, Megumi Suzuki, Tadashi Kagoshima, Takehito Nakai, Toshio Hashimoto, Yoshiharu Nishitani, Yoshiyuki Kobayashi, Koichi Hoda, Junko Uejima, Yoshinobu Morikawa, Takahiro Kawano, Hideki Yamada, Kazuo Nishimoto, Kyouyuki Ohsumi, Nobushige Ote, Akiko Oya, Kimiaki Nishiura, Joji Masuda, Keiichiro Ban, Yusuke Kyoda, Izumi Sawada, Yoko Sawada, Koichi Okada, Akihiro Yazaki, Masakazu Hanatani, Toshio Sutani, Yuko Hiramori, Yuya Tanaka, Toshiro Igaki, Yukio Tomioka, Hideo Shiiki, Kiyotaka Sugihara, Motomu Hayashi, Yasunobu Sasaki, Yasuo Matsukura, Michiaki Ueda, Masakuni Ueyama, Hideto Uyama, Hiroharu Yamada, Kenichi Yamaga, Tamio Nakajima, Kazumi Yoshimoto, Midori Yoshimura

Affiliations

¹ Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. yuuki@gpo.kumamoto-u.ac.jp.
² Health Care Center, Kumamoto University, Kumamoto, Japan. yuuki@gpo.kumamoto-u.ac.jp.
³ Kumamoto University, Kumamoto, Japan.
⁴ Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan.
⁵ Department of Diabetes and Endocrinology, Nara Medical University, Kashihara, Japan.
⁶ Department of Cardiology, Center for Health Surveillance & Preventive Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
⁷ Nakayama Cardiovascular Clinic, Amakusa, Japan.
⁸ Internal Medicine, Koseikai Clinic, Kyoto, Japan.
⁹ Department of Internal Medicine, Jinnouchi Hospital Diabetes Care Center, Kumamoto, Japan.
¹⁰ Food Safety Commission of Japan, Tokyo, Japan.
¹¹ Nara Prefecture Seiwa Medical Center, Sango-cho, Japan.

PMID: 37522902
DOI: 10.1007/s00380-023-02291-4

Randomized Controlled Trial

Dipeptidyl peptidase-4 inhibitors reduce the incidence of first cardiovascular events in Japanese diabetic patients

Hirofumi Soejima et al. Heart Vessels. 2023 Nov.

. 2023 Nov;38(11):1371-1379.

doi: 10.1007/s00380-023-02291-4. Epub 2023 Jul 31.

Authors

Collaborators

JPAD Trial Investigators:
Kimiaki Miwa, Kazunobu Akahoshi, Kenji Misumi, Haruo Araki, Yutaka Mitsudo, Norifumi Kondo, Kenichi Ashihara, Shinya Yumoto, Masashi Horimoto, Osamu Doi, Kenichi Doijiri, Ryo Fukami, Michio Shimabukuro, Genshi Egusa, Kazuo Goto, Yoichi Hanaoka, Yoshihiro Kimura, Yoshikuni Haraguchi, Osamu Haraguchi, Atsushi Hasegawa, Yoshiko Shioya, Yosuke Shioya, Eiitiro Tanaka, Kazuhiko Yamada, Toshiya Atsumi, Satoshi Tanazawa, Yutaka Horio, Seishi Ichihara, Isao Yasuda, Tsuneo Ikeda, Makoto Ikemura, Chieko Imamoto, Yoshihisa Iseri, Ken Iwai, Shinya Okamoto, Seigo Sugiyama, Masanori Kamura, Hirofumi Kan, Mayumi Kiyota, Kyousuke Kawamura, Takashi Ono, Takeshi Koga, Etsuo Kinuwaki, Hiromichi Naito, Kazuo Kozuma, Kiyotaka Kudou, Yasuhiro Morikami, Hirofumi Yasue, Yuji Mizuno, Hisao Fujimoto, Kozaburo Matsuyama, Hiromi Fujii, Syuichi Kamijikkoku, Tetsuo Kuwahara, Kyoji Takaoka, Kazuo Machii, Kazutaka Maeda, Keiji Mahara, Akira Maki, Naoki Manda, Kousuke Marutsuka, Naoki Sameshima, Toshihiro Gi, Terufumi Matsunaga, Syuichi Matsuo, Hiroto Okubo, Fuyuki Minagawa, Kotaro Minoda, Junichi Miyata, Takeshi Matsuo, Sueo Momosaki, Tetsuo Munakata, Tomoki Nakamura, Hisatoshi Nagano, Kazuto Goshi, Keisuke Sugimoto, Shojiro Naomi, Toshiaki Nasu, Hiroyuki Tanaka, Ryuji Sonoda, Keizo Kajiwara, Takafumi Odo, Hirofumi Ogata, Masayuki Ogihara, Tateo Ogura, Keishiro Oka, Eiji Kawashima, Eiji Oshima, Ken Ozaki, Seiji Ozawa, Hiroyuki Shono, Yasuhiro Sakamoto, Nobuko Sakurai, Chikashi Wakabayashi, Tomohiro Sawada, Junji Shibata, Hisashi Shimono, Akihiro Iemura, Akira Matsutani, Hisakazu Suefuji, Hiromichi Sugiyama, Jun Hokamaki, Kenichi Komori, Yoshimi Kinoshita, Hironori Murakami, Jun Hashiguchi, Yasuhiro Hashiguchi, Koryo Sawai, Atuko Hifumi, Koji Seo, Masamitsu Toihata, Koji Tokube, Hiroshi Ogawa, Fumishi Tomita, Madoka Taguchi, Toshio Tsubokura, Tatsuaki Tsuchiya, Kaoru Tsuda, Ryuichiro Tsurusaki, Kenji Obata, Katumi Watanabe, Raisuke Hayasida, Yutaka Ishibashi, Yoshiaki Osamura, Yoshito Yamanaka, Kazuhiro Sonoda, Taisuke Iwaoka, Hiromitsu Yokota, Motoki Yoshinari, Nanami Abe, Noriaki Ando, Hiroshi Bando, Takeshi Takami, Michiaki Doi, Yoshihiro Fujii, Masahiro Fukuda, Yoshiaki Fukuoka, Masayoshi Hamano, Minoru Takaoka, Hiromi Hasegawa, Ikuo Yabuta, Kenshi Higami, Satomi Higami, Akiko Yasuno, Yuriko Fujinaga, Yoko Onishi, Katsutoshi Yoshimura, Shigetoshi Minami, Takao Nakashima, Hiroaki Horie, Kazuko Horii, Norihiko Matsumura, Tetsuo Ikuno, Yoshiyuki Katsuyama, Shiro Uemura, Masao Kikukawa, Masao Kanauchi, Hideshi Kuzuya, Arata Iwasaki, Takehiko Koutani, Hisaharu Makino, Hiroshi Miki, Susumu Misugi, Masaki Naito, Masatoshi Naito, Yukitaka Nakano, Akira Nakatani, Fumihiko Nakatani, Manabu Horii, Matahiro Yabuta, Ayako Seno, Hiroyuki Kawata, Kenichi Samejima, Kenji Onoue, Rika Kawakami, Tomoya Nakano, Tomoya Ueda, Tsunenari Soeda, Yoko Kita, Fumitaka Inoue, Shigeru Yamano, Hajime Iwama, Hirokazu Sakan, Megumi Suzuki, Tadashi Kagoshima, Takehito Nakai, Toshio Hashimoto, Yoshiharu Nishitani, Yoshiyuki Kobayashi, Koichi Hoda, Junko Uejima, Yoshinobu Morikawa, Takahiro Kawano, Hideki Yamada, Kazuo Nishimoto, Kyouyuki Ohsumi, Nobushige Ote, Akiko Oya, Kimiaki Nishiura, Joji Masuda, Keiichiro Ban, Yusuke Kyoda, Izumi Sawada, Yoko Sawada, Koichi Okada, Akihiro Yazaki, Masakazu Hanatani, Toshio Sutani, Yuko Hiramori, Yuya Tanaka, Toshiro Igaki, Yukio Tomioka, Hideo Shiiki, Kiyotaka Sugihara, Motomu Hayashi, Yasunobu Sasaki, Yasuo Matsukura, Michiaki Ueda, Masakuni Ueyama, Hideto Uyama, Hiroharu Yamada, Kenichi Yamaga, Tamio Nakajima, Kazumi Yoshimoto, Midori Yoshimura

Affiliations

¹ Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. yuuki@gpo.kumamoto-u.ac.jp.
² Health Care Center, Kumamoto University, Kumamoto, Japan. yuuki@gpo.kumamoto-u.ac.jp.
³ Kumamoto University, Kumamoto, Japan.
⁴ Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan.
⁵ Department of Diabetes and Endocrinology, Nara Medical University, Kashihara, Japan.
⁶ Department of Cardiology, Center for Health Surveillance & Preventive Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
⁷ Nakayama Cardiovascular Clinic, Amakusa, Japan.
⁸ Internal Medicine, Koseikai Clinic, Kyoto, Japan.
⁹ Department of Internal Medicine, Jinnouchi Hospital Diabetes Care Center, Kumamoto, Japan.
¹⁰ Food Safety Commission of Japan, Tokyo, Japan.
¹¹ Nara Prefecture Seiwa Medical Center, Sango-cho, Japan.

PMID: 37522902
DOI: 10.1007/s00380-023-02291-4

Abstract

Background: Dipeptidyl Peptidase-4 (DPP-4) inhibitors do not suppress cardiovascular events in diabetic patients with a history of cardiovascular disease. However, the effect of DPP-4 inhibitors on cardiovascular events in Japanese diabetic patients is unclear. Therefore, we investigated whether DPP-4 inhibitors alter the incidence of cardiovascular events in Japanese diabetic patients without a history of cardiovascular events.

Methods: The Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial was a multicenter, prospective, randomized, open label, blinded, end-point study conducted from 2002 to 2008. After completion of the JPAD trial, we followed up the patients until 2019. Patients who had had a cardiovascular event by the 2013 follow-up were excluded from the study. JPAD patients were divided into a DPP-4 group and a non-DPP-4 group based on whether they were taking DPP-4 inhibitors at the 2013 follow-up because few patients took DPP-4 inhibitors before 2013. We investigated the incidence of cardiovascular events consisting of coronary events, cerebrovascular events, heart failure requiring hospitalization, and aortic and peripheral vascular disease in 1099 JPAD patients until 2019.

Results: During the observation period from 2013 to 2019, 37 (7%) first cardiovascular events occurred in the DPP-4 group (n = 518) and 66 (11%) in the non-DPP-4 group (n = 581). The incidence of cardiovascular events was significantly lower in the DPP-4 group than in the non-DPP-4 group (Log-Rank P = 0.0065). Cox proportional hazards model analysis revealed that the use of DPP-4 inhibitors (hazard ratio 0.65; 95% confidence interval 0.43-0.98; P = 0.038) was an independent factor after adjustment for age ≥ 65 years, hypertension, statin usage, and insulin usage.

Conclusions: Our findings have demonstrated that the use of DPP-4 inhibitors may be associated with a reduced incidence of first cardiovascular events in Japanese diabetic patients. The results require confirmation in randomized controlled trials.

Keywords: Cardiovascular events; Diabetes mellitus; Dipeptidyl peptidase-4 inhibitors; Primary prevention.

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References

1. Scheen AJ, Paquot N (2012) Gliptin versus a sulphonylurea as add-on to metformin. Lancet 380:450–452 - DOI - PubMed
1. Deacon CF, Lebovitz HE (2016) Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas. Diabetes Obes Metab 18:333–347 - DOI - PubMed
1. Monami M, Iacomelli I, Marchionni N, Mannucci E (2010) Dipeptydil peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 20:224–235 - DOI - PubMed
1. Law MR, Morris JK, Wald NJ (2009) Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomized trials in the context of expectations from prospective epidemiological studies. BMJ 338:b1665 - DOI - PubMed - PMC
1. Horton ES, Silberman C, Davis KL, Berria R (2010) Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database. Diabetes Care 33:1759–1765 - DOI - PubMed - PMC

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Dipeptidyl peptidase-4 inhibitors reduce the incidence of first cardiovascular events in Japanese diabetic patients

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Dipeptidyl peptidase-4 inhibitors reduce the incidence of first cardiovascular events in Japanese diabetic patients

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