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Review
. 2023 Oct:123:110694.
doi: 10.1016/j.intimp.2023.110694. Epub 2023 Jul 29.

Immune cells in pemphigus vulgaris and bullous Pemphigoid: From pathogenic roles to targeting therapies

Qiuyun Yuan  1 , Wanchun Yang  2 , Xuefeng Zhang  3
Affiliations
Review

Immune cells in pemphigus vulgaris and bullous Pemphigoid: From pathogenic roles to targeting therapies

Qiuyun Yuan et al. Int Immunopharmacol. 2023 Oct.

Abstract

Pemphigus vulgaris (PV) and bullous pemphigoid (BP) are two major subtypes of autoimmune bullous diseases (AIBD), characterized by blisters and erosions of skin and/or mucous membranes with dysregulated immune activity. Current literature established that T and B cells are the main executors of PV and BP. Emerging evidence revealed that macrophages and related cytokines also contribute to these diseases. While the role of lymphocytes on PV and BP is well established, the definitive functions of macrophages in disease progression are not fully understood. Furthermore, current status of clinical trials targeting immune cells is poorly recapitulated in PV and BP. In this review, we summarized current knowledge in this rapidly advancing field, with emphasis on the individual functions of immune cells and their interactions, as well as ongoing clinical trials targeting immune cells, to provide novel insights in mechanistic understanding and clinical management of PV and BP.

Keywords: Autoimmunity; Bullous pemphigoid; Lymphocytes; Macrophage; Pemphigus vulgaris.

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Conflict of interest statement

Declaration of Competing Interest This research was funded by the National Natural Science Foundation of China (No. 82002877) and Sichuan Science and Technology Program (No. 2023YFSY0042). The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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