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Review
. 2023 Jul;23(4):284-291.
doi: 10.7861/clinmed.2023-0168.

Causes of obesity: a review

Beenish Masood  1 , Myuri Moorthy  2
Affiliations
Review

Causes of obesity: a review

Beenish Masood et al. Clin Med (Lond). 2023 Jul.

Abstract

Obesity research is advancing swiftly, but the increase in obesity prevalence is faster. Over the past three decades, researchers have found that biopsychosocial factors determine weight gain much more than personal choices and responsibility. Various genes have found to predispose people to obesity by interacting with our obesogenic environment. In this review, we discuss the impact of physical inactivity, excessive caloric intake, intrauterine environment, postnatal influences, insufficient sleep, drugs, medical conditions, socioeconomic status, ethnicity, psychosocial stress, endocrine disrupting chemicals and the gastrointestinal microbiome, on the occurrence of obesity.

Keywords: causes; environment; epigenetics; genetics; modifiable; modifiable factors; obesity.

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References

    1. Butland B, Jebb S, Kopelman P, et al. FORESIGHT-tackling obesities: future choices, 2nd edn. London; Government Office for Science, 2007. - PubMed
    1. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903–8. - PubMed
    1. Clément K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398–401. - PubMed
    1. Jackson RS, Creemers JW, Ohagi S, et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 1997;16:303–6. - PubMed
    1. Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997;88:131–41. - PubMed