Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2023 Jul 31;23(1):530.
doi: 10.1186/s12903-023-03243-0.

The effect of low-dose aspirin on aspirin triggered lipoxin, interleukin 1 beta, and prostaglandin E2 levels in periapical fluid: a double-blind randomized clinical trial

Elham Khoshbin  1 , Razieh Salehi  1   2 , Rooholah Behroozi  1 , Soroush Sadr  1 , Alireza Zamani  3 , Maryam Farhadian  4 , Hamed Karkehabadi  5   6
Affiliations
Randomized Controlled Trial

The effect of low-dose aspirin on aspirin triggered lipoxin, interleukin 1 beta, and prostaglandin E2 levels in periapical fluid: a double-blind randomized clinical trial

Elham Khoshbin et al. BMC Oral Health. .

Abstract

Background: The role of pro-resolving mediators in inflammation is a new concern in research. The effect of low-dose aspirin on production of a special kind of these mediators named aspirin triggered lipoxin (ATL) has been studied on different tissues. This randomized clinical trial evaluated the effect of low-dose aspirin on ATL and pro-inflammatory mediators' level in periapical fluid of necrotic teeth with large lesions.

Methods: Twenty-four patients with necrotic pulp and periapical lesion were randomly assigned to low-dose aspirin and placebo groups. In the first appointment, canals were shaped up to F3 size and #40 K-file and cleaned with 10 milliliters 2.5% sodium hypochlorite and 17% Ethylenediaminetetraacetic acid. Periapical fluid was sampled by a paper cone. The tooth was temporized without any intracanal medication. Tablets were administered for 7 days, then the teeth were re-opened and the sampling were repeated. Interleukin-1 beta (IL-1β), prostaglandin E2 (PGE2) and ATL were analyzed by enzyme-linked immunosorbent assay. Data were analyzed with paired t-test using SPSS statistical software, version 21 (α = 0.05).

Results: A significant reduction in PGE2 and IL-1β was noted in the aspirin-treated group while an increase in ATL was observed (P < 0.001). There was no significant difference in the mediator scores before and after in the placebo-treated group (P > 0.05).

Conclusion: Low-dose aspirin can influence the inflammatory process by reducing pro-inflammatory mediators such as PGE2 and IL-1β, as well as increasing the pro-resolving mediators such as ATL.

Trial registration: IRCT20191211045702N1.

Keywords: Aspirin triggered lipoxin; Interleukin 1 beta; Low-dose aspirin; Prostaglandin E2; Specialized pro-resolving mediators.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests in this section.

Figures

Fig. 1
Fig. 1
Graphic representation of the mediator levels before and after treatment in test and placebo group. (A) Prostaglandin E2 level (B) Interleukin-1β level (C) Aspirin triggered lipoxin level. * significant difference, p < 0.001
See this image and copyright information in PMC

References

    1. Ehsani M, Moghadamnia A-A, Zahedpasha S, et al. The role of prophylactic ibuprofen and N-acetylcysteine on the level of cytokines in periapical exudates and the post-treatment pain. Daru: J Fac Pharm Tehran Univ Med Sci. 2012;20(1):30. doi: 10.1186/2008-2231-20-30. - DOI - PMC - PubMed
    1. Shahriari S, Rezaei A, Jalalzadeh SM, et al. Effect of Ibuprofen on IL-1beta, TNF-alpha and PGE2 levels in periapical exudates: a double blinded clinical trial. Iran J Immunol. 2011;8(3):176–82. - PubMed
    1. Ataoğlu T, Üngör M, Serpek B et al. Interleukin-1β and tumour necrosis factor‐α levels in periapical exudates. 2002;35(2):181–5. - PubMed
    1. Serhan CN. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J Periodontol. 2008;79(8 Suppl):1520–6. doi: 10.1902/jop.2008.080231. - DOI - PubMed
    1. Serhan CNJTFJ. Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms. 2017;31(4):1273–88. - PMC - PubMed

Publication types

LinkOut - more resources