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. 2023 Aug 1;6(8):e2326542.
doi: 10.1001/jamanetworkopen.2023.26542.

Sex Vulnerabilities to Hypoxia-Ischemia at Birth

Lina F Chalak  1   2 , Jessica E Pruszynski  3 , Catherine Y Spong  2   3
Affiliations

Sex Vulnerabilities to Hypoxia-Ischemia at Birth

Lina F Chalak et al. JAMA Netw Open. .
No abstract available

Plain language summary

This cross-sectional study examines the incidence of hypoxic ischemic encephalopathy in male vs female neonates.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.. Secondary Analysis of Sex-Stratified Neonatal Outcomes
HIE indicates hypoxic ischemic encephalopathy; NICU, neonatal intensive care unit.
See this image and copyright information in PMC

References

    1. Wood TR, Gundersen JK, Falck M, et al. . Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic-ischaemic brain injury: a single laboratory meta-analysis. Sci Rep. 2020;10(1):10833. doi:10.1038/s41598-020-67532-2 - DOI - PMC - PubMed
    1. Roy-O’Reilly M, McCullough LD. Age and sex are critical factors in ischemic stroke pathology. Endocrinology. 2018;159(8):3120-3131. doi:10.1210/en.2018-00465 - DOI - PMC - PubMed
    1. Durán-Carabali LE, Da Silva JL, Colucci ACM, Netto CA, De Fraga LS. Protective effect of sex steroid hormones on morphological and cellular outcomes after neonatal hypoxia-ischemia: a meta-analysis of preclinical studies. Neurosci Biobehav Rev. 2023;145:105018. doi:10.1016/j.neubiorev.2022.105018 - DOI - PubMed
    1. Wyatt JS, Gluckman PD, Liu PY, et al. ; CoolCap Study Group . Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics. 2007;119(5):912-921. doi:10.1542/peds.2006-2839 - DOI - PubMed
    1. Sewell EK, Shankaran S, Natarajan G, et al. . Evaluation of heterogeneity in effect of therapeutic hypothermia by sex among infants with neonatal encephalopathy. Pediatr Res. Published online April 3, 2023. doi:10.1038/s41390-023-02586-2 - DOI - PMC - PubMed

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