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Review
. 2023 Nov;16(11):e202300182.
doi: 10.1002/jbio.202300182. Epub 2023 Aug 22.

Photobiomodulation in diabetic rats: Effects on morphological, pancreatic parameters, and glucose homeostasis

Isabella Liba Pandolfo  1 , Mirian Bonifacio  1 , Izabelle Dias Benfato  1 , Matheus de Almeida Cruz  1 , Márcia Regina Nagaoka  1 , Carolina Prado de França Carvalho  1 , Camila Aparecida Machado de Oliveira  1 , Ana Cláudia Muniz Renno  1
Affiliations
Review

Photobiomodulation in diabetic rats: Effects on morphological, pancreatic parameters, and glucose homeostasis

Isabella Liba Pandolfo et al. J Biophotonics. 2023 Nov.

Abstract

Photobiomodulation (PBM) has therapeutic effects on wound healing, diabetic microangiopathy, and retinopathy. However, little is known about the use of PBM for the treatment of diabetes mellitus (DM). In this context, we aimed to evaluate the effects of PBM on pancreas morphology and insulin and glucose tolerance in an experimental model of DM. Thus, DM was induced by streptozotocin (STZ) (60 mg/kg). Subsequently, the rats were treated with PBM (808 nm and 30 J/cm2 ). After euthanasia, morphometric parameters and immunoreactivity for insulin and 8-OHdG were evaluated in the pancreas. The results showed that treated animals had higher values of body mass and higher values in the number of beta cells in the pancreas. In conclusion, PBM resulted in decreased weight loss in STZ-induced diabetic rats and presented a stimulatory effect on the pancreas of the treated animals, highlighting the promising effects of this therapy in the clinical condition of DM.

Keywords: glucose homeostasis; photobiomodulation; streptozotocin model; type 1 diabetes.

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References

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