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. 2023 Jul 30;15(3):e12466.
doi: 10.1002/dad2.12466. eCollection 2023 Jul-Sep.

Trends in the incidence of dementia in people with hypertension in the UK 2000 to 2021

Matthew Adesuyan  1   2 , Yogini H Jani  1   2 , Dana Alsugeir  1   3 , Robert Howard  4 , Ian C K Wong  1   2   5 , Li Wei  1 , Ruth Brauer  1
Affiliations

Trends in the incidence of dementia in people with hypertension in the UK 2000 to 2021

Matthew Adesuyan et al. Alzheimers Dement (Amst). .

Abstract

Introduction: We investigated trends in the incidence of dementia in UK adults with hypertension.

Methods: Primary care electronic health records from IQVIA Medical Research Data UK, previously known as THIN, were used to identify 2,133,118 adults aged ≥40 years with hypertension over 2000 to 2021. The annual incidence rate and average annual percentage change in recorded dementia diagnoses were estimated and stratified by sex, 10-year age bands, Townsend deprivation quintiles and dementia subtype.

Results: The crude incidence rate of dementia in people with hypertension increased from 1.98 (95% confidence internal [CI] 1.89-2.07) per 1000 person-years at risk (PYAR) in 2000 to 5.29 per 1000 PYAR (95% CI 5.07-5.53) in 2021, corresponding to an average annual increase of 4.1% (95% CI 3.3-5.0). Those aged ≥80 years, the most economically deprived (Townsend = 5), and Alzheimer's disease subtype reported the highest incidence rate within their respective categories.

Discussion: The annual incidence rate of dementia in the hypertensive population has increased over the last 22 years.

Highlights: New dementia diagnosis in the hypertensive population has increased over 22 years.The Alzheimer's disease subtype reported the highest incidence rate in people with hypertension.Difference in dementia incidence between hypertensive females and males has reduced.Difference in dementia incidence among deprivation categories has reduced in recent years.

Keywords: dementia; electronic health records; epidemiology; hypertension; incidence.

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Conflict of interest statement

Mr. Matthew Adesuyan, Dr. Yogini H. Jani, Ms. Dana Alsugeir, Professor Robert Howard, Professor Li Wei, and Dr. Ruth Brauer all have no conflicts of interest to declare in relation to the subject matter and content discussed in this manuscript. Author disclosures are available in the supporting information.

Figures

FIGURE 1
FIGURE 1
Annual incidence rate of dementia in the hypertensive population 2000–2021. PYAR, person‐years at risk.
FIGURE 2
FIGURE 2
Sex‐stratified annual incidence rate of dementia in the hypertensive population 2000–2021. PYAR, person‐years at risk.
FIGURE 3
FIGURE 3
Age‐stratified annual incidence rate of dementia in the hypertensive population 2000–2021. PYAR, person‐years at risk.
FIGURE 4
FIGURE 4
Townsend quintile stratified annual incidence rate of dementia in the hypertensive population 2000–2021. PYAR, person‐years at risk.
FIGURE 5
FIGURE 5
Dementia subtype stratified annual incidence rate of dementia in the hypertensive population 2000–2021. PYAR, person‐years at risk.
See this image and copyright information in PMC

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