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. 2023 Jul 15;25(7):685-688.
doi: 10.7499/j.issn.1008-8830.2302126.

[Multisystemic inflammatory syndrome in children after severe acute respiratory syndrome coronavirus 2 infection: a clinical analysis of four cases]

[Article in Chinese]
Fei Wang  1 , Lu Liu  1 , Ying Xue  1 , Shi Dan  1 , Xin-Jiang An  1
Affiliations

[Multisystemic inflammatory syndrome in children after severe acute respiratory syndrome coronavirus 2 infection: a clinical analysis of four cases]

[Article in Chinese]
Fei Wang et al. Zhongguo Dang Dai Er Ke Za Zhi. .

Abstract
in English, Chinese

Objectives: To investigate the clinical features and treatment strategies of multisystemic inflammatory syndrome in children (MIS-C) after severe acute respiratory syndrome coronavirus 2 infection.

Methods: A retrospective analysis was performed on the medical data of four children with MIS-C who were admitted to the Department of Cardiology, Xuzhou Children's Hospital, Xuzhou Medical Universityfrom January to February 2023.

Results: All four children had multiple organ involvements and elevated inflammatory markers, with a poor response to standard therapy for Kawasaki disease after admission. Two children were treated with intravenous immunoglobulin therapy pulse therapy twice, and all four children were treated with glucocorticoids. The children had a good prognosis after the treatment.

Conclusions: MIS-C often appears within 4-6 weeks or a longer time after severe acute respiratory syndrome coronavirus 2 infection, and anti-inflammatory therapy in addition to the standard treatment regimen for Kawasaki disease can help to achieve a favorable treatment outcome.

目的: 探讨新型冠状病毒感染后儿童多系统炎症综合征（multisystem inflammatory syndrome in children，MIS-C）患儿的临床特征及诊治策略。方法: 对徐州医科大学附属徐州儿童医院心血管内科2023年1—2月收治的4例MIS-C患儿的病例资料进行回顾性分析。结果: 4例患儿均伴有多脏器功能受累及炎症指标升高，入院后接受川崎病标准治疗方案效果不理想，其中2例予2次静脉注射免疫球蛋白冲击治疗，4例均加用糖皮质激素抗炎治疗，积极治疗后患儿预后良好。结论: MIS-C常出现在新型冠状病毒感染后4~6周或更长时间，及时在川崎病标准治疗方案基础上加强抗炎治疗可取得良好治疗效果。.

Keywords: Child; Kawasaki-like disease; Multisystemic inflammatory syndrome in children; Severe acute respiratory syndrome coronavirus 2.

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Conflict of interest statement

所有作者均声明不存在利益冲突。

References

    1. Brodsky NN, Ramaswamy A, Lucas CL. The mystery of MIS-C post-SARS-CoV-2 infection[J]. Trends Microbiol, 2020, 28(12): 956-958. DOI: 10.1016/j.tim.2020.10.004. - DOI - PMC - PubMed
    1. Whittaker E, Bamford A, Kenny J, et al. . Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2[J]. JAMA, 2020, 324(3): 259-269. DOI: 10.1001/jama.2020.10369. - DOI - PMC - PubMed
    1. Viner RM, Whittaker E. Kawasaki-like disease: emerging complication during the COVID-19 pandemic[J]. Lancet, 2020, 395(10239): 1741-1743. DOI: 10.1016/S0140-6736(20)31129-6. - DOI - PMC - PubMed
    1. World Health Organization . Multisystem inflammatory syndrome in children and adolescents with COVID-19[EB/OL]. (2020-05-15)[2023-02-15]. https://www.who.int/publications/i/item/multisystem-inflammatory-syndrom....
    1. Riphagen S, Gomez X, Gonzalez-Martinez C, et al. . Hyperinflammatory shock in children during COVID-19 pandemic[J]. Lancet, 2020, 395(10237): 1607-1608. DOI: 10.1016/S0140-6736(20)31094-1. - DOI - PMC - PubMed

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