Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 1;32(5):404-411.
doi: 10.1097/MNH.0000000000000908. Epub 2023 Jun 30.

Renal denervation: recent developments in clinical and preclinical research

Paul Drawz  1 , Daniel Baumann  2 , Alex Dayton  1
Affiliations
Review

Renal denervation: recent developments in clinical and preclinical research

Paul Drawz et al. Curr Opin Nephrol Hypertens. .

Abstract

Purpose of review: Renal denervation represents a new dimension to hypertension treatment, with multiple device manufacturers seeking premarket FDA approval currently. Interest in the efficacy and safety of the treatment has spurred compelling mechanistic studies into the function of renal nerves and downstream impacts of denervation.

Recent findings: A trial of the ultrasound Paradise Catheter system (RADIANCE II) found a 6.3 mmHg reduction in SBP relative to sham controls. A trial of the Symplicity Spyral system (SPYRAL HTN-ON MED) found an insignificant reduction in SBP relative to sham controls. Individuals were taking antihypertensive medications during the study, and investigators note the sham group experienced a larger medication burden than the denervated group. Recent preclinical studies have evaluated potential risks of renal denervation, how sympathetic activity broadly is affected, as well as identifying possible biomarkers to identify individuals where denervation would be more successful.

Summary: Studies of renal denervation continue to find a robust antihypertensive effect, especially in studies wherein medications are withdrawn. Further investigation into mechanisms and indicators for usage of the technique will be important in identifying the patient population most likely to benefit from usage of renal denervation.

PubMed Disclaimer

References

    1. Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380:2224–2260.
    1. Berra E, Azizi M, Capron A, et al. Evaluation of adherence should become an integral part of assessment of patients with apparently treatment-resistant hypertension. Hypertension 2016; 68:297–306.
    1. Mahfoud F, Renkin J, Sievert H, et al. Alcohol-mediated renal denervation using the Peregrine System Infusion Catheter for treatment of hypertension. JACC Cardiovasc Interv 2020; 13:471–484.
    1. Hering D, Nikoleishvili D, Imedadze A, et al. Transurethral renal pelvic denervation: a feasibility trial in patients with uncontrolled hypertension. Hypertension 2022; 79:2787–2795.
    1. Mauri L, Kario K, Basile J, et al. A multinational clinical approach to assessing the effectiveness of catheter-based ultrasound renal denervation: the RADIANCE-HTN and REQUIRE clinical study designs. Am Heart J 2018; 195:115–129.

Substances