Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Aug 15;120(33):e2309992120.
doi: 10.1073/pnas.2309992120. Epub 2023 Aug 2.

Bridging a mechanistic gap from diet to synapses

Deanna L Benson  1 , Sophie Layé  2
Affiliations
Comment

Bridging a mechanistic gap from diet to synapses

Deanna L Benson et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Nutrients provided in breastmilk aid cognitive development (solid arrow). The impact they have on synapses likely occurs through modifications of lipid bilayer composition, particularly within synapses (boxed region in transmission electron microscope image of glutamatergic synapse). The figure was made in BioRender.com using an image captured on a Hitatchi 7700 microscope in the Microscopy and Advanced Bioimaging Core at Mount Sinai.
See this image and copyright information in PMC

Comment on

  • The human milk component myo-inositol promotes neuronal connectivity.
    Paquette AF, Carbone BE, Vogel S, Israel E, Maria SD, Patil NP, Sah S, Chowdhury D, Kondratiuk I, Labhart B, Morrow AL, Phillips SC, Kuang C, Hondmann D, Pandey N, Biederer T. Paquette AF, et al. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2221413120. doi: 10.1073/pnas.2221413120. Epub 2023 Jul 11. Proc Natl Acad Sci U S A. 2023. PMID: 37433002 Free PMC article.

References

    1. Ballard O., Morrow A. L., Human milk composition: Nutrients and bioactive factors. Pediatr Clin. North Am. 60, 49–74 (2013). - PMC - PubMed
    1. Paquette A. F., The human milk component myo-inositol promotes neural connectivity. Proc. Natl. Acad. Sci. U.S.A. 120, e2221413120 (2023). - PMC - PubMed
    1. Michell R. H., Inositol derivatives: Evolution and functions. Nat. Rev. Mol. Cell Biol. 9, 151–161 (2008). - PubMed
    1. Clements R. S., Darnell B., Myo-inositol content of common foods: Development of a high-myo-inositol diet. Am. J. Clin. Nutr. 33, 1954–1967 (1980). - PubMed
    1. Su X. B., Ko A.-L.A., Saiardi A., Regulations of myo-inositol homeostasis: Mechanisms, implications, and perspectives. Adv. Biol. Regul. 87, 100921 (2023). - PubMed

Publication types

LinkOut - more resources