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. 2023 Aug 8;82(6):473-485.
doi: 10.1016/j.jacc.2023.05.046.

High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease

Ryan Wereski  1 , Philip Adamson  2 , Nur Shazlin Shek Daud  3 , Michael McDermott  3 , Caelan Taggart  3 , Anda Bularga  3 , Dorien M Kimenai  3 , Mathew T H Lowry  3 , Chris Tuck  3 , Atul Anand  3 , David J Lowe  4 , Andrew R Chapman  5 , Nicholas L Mills  6
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High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease

Ryan Wereski et al. J Am Coll Cardiol. .
Free article

Abstract

Background: Cardiac troponin is used for risk stratification of patients with acute coronary syndromes; however, the role of testing in other settings remains unclear.

Objectives: The aim of this study was to evaluate whether cardiac troponin testing could enhance risk stratification in patients with chronic coronary artery disease independent of disease severity and conventional risk measures.

Methods: In a prospective cohort of consecutive patients with symptoms suggestive of stable angina attending for outpatient coronary angiography, high-sensitivity cardiac troponin I was measured before angiography, and clinicians were blinded to the results. The primary outcome was myocardial infarction or cardiovascular death during follow-up.

Results: In 4,240 patients (age 66 years [IQR: 59-73 years], 33% female), coronary artery disease was identified in 3,888 (92%) who had 255 (6%) primary outcome events during a median follow-up of 2.4 years (IQR: 1.3-3.6 years). In patients with coronary artery disease, troponin concentrations were 2-fold higher in those with an event compared with those without (6.7 ng/L [IQR: 3.2-14.2 ng/L] vs 3.3 ng/L [IQR: 1.7-6.6 ng/L]; P < 0.001). Troponin concentrations were associated with the primary outcome after adjusting for cardiovascular risk factors and coronary artery disease severity (adjusted HR: 2.3; 95% CI: 1.7-3.0, log10 troponin; P < 0.001). A troponin concentration >10 ng/L identified patients with a 50% increase in the risk of myocardial infarction or cardiovascular death.

Conclusions: In patients with chronic coronary artery disease, cardiac troponin predicts risk of myocardial infarction or cardiovascular death independent of cardiovascular risk factors and disease severity. Further studies are required to evaluate whether routine testing could inform the selection of high-risk patients for treatment intensification. (Myocardial Injury in Patients Referred for Coronary Angiography [MICA]; ISRCTN15620297).

Keywords: cardiac troponin; chronic coronary artery disease; coronary angiography; myocardial infarction; risk prediction.

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Conflict of interest statement

Funding Support and Author Disclosures The study was funded by a Programme Grant from the British Heart Foundation (RG/20/10/34966). Drs Wereski and Bularga are supported by Clinical Research Training Fellowships (MR/V007017/1, MR/V007254/1) from the Medical Research Council. Dr Kimenai is supported by a grant from Health Data Research UK. Dr Chapman receives support from a Starter Grant for Clinical Lecturers by the Academy of Medical Sciences (SGL021/1075). Dr Mills is supported by a Chair Award and Research Excellence Award (CH/F/21/90010, RE/18/5/34216) from the British Heart Foundation. This work was supported by DataLoch, which is funded by the Data Driven Innovation programme within the Edinburgh and South East Scotland City Region Deal. The funders played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Dr Mills has received honoraria from Abbott Diagnostics, Siemens Healthineers, Roche Diagnostics, and LumiraDx; and the University of Edinburgh has received research grants from Abbott Diagnostics and Siemens Healthineers. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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