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Comment
. 2023 Sep;9(9):700-702.
doi: 10.1016/j.trecan.2023.07.005. Epub 2023 Aug 1.

Cys-regulation: oxidized CHK1 controls cross-compartment circuit of chemoresistance

Nathan P Ward  1
Affiliations
Comment

Cys-regulation: oxidized CHK1 controls cross-compartment circuit of chemoresistance

Nathan P Ward. Trends Cancer. 2023 Sep.

Abstract

In a recent study published in Cell, Zhang et al. integrate genome-wide CRISPRi screening with cysteine chemoproteomics to identify functionally relevant oxidation events associated with the cellular response to chemotherapy. This work uncovered checkpoint kinase 1 (CHK1) as a nuclear reactive oxygen species (ROS) sensor that mediates chemoresistance through the suppression of mitochondrial protein synthesis.

Keywords: CHK1; ROS; SSBP1; chemoresistance; redox.

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Conflict of interest statement

Declaration of interests No interests are declared.

Comment on

  • Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
    Zhang J, Simpson CM, Berner J, Chong HB, Fang J, Ordulu Z, Weiss-Sadan T, Possemato AP, Harry S, Takahashi M, Yang TY, Richter M, Patel H, Smith AE, Carlin AD, Hubertus de Groot AF, Wolf K, Shi L, Wei TY, Dürr BR, Chen NJ, Vornbäumen T, Wichmann NO, Mahamdeh MS, Pooladanda V, Matoba Y, Kumar S, Kim E, Bouberhan S, Oliva E, Rueda BR, Soberman RJ, Bardeesy N, Liau BB, Lawrence M, Stokes MP, Beausoleil SA, Bar-Peled L. Zhang J, et al. Cell. 2023 May 25;186(11):2361-2379.e25. doi: 10.1016/j.cell.2023.04.026. Epub 2023 May 15. Cell. 2023. PMID: 37192619 Free PMC article.

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