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. 2023 Jul 19;9(8):e18431.
doi: 10.1016/j.heliyon.2023.e18431. eCollection 2023 Aug.

Dental scaling and lower risk of spontaneous intracranial hemorrhage

Affiliations

Dental scaling and lower risk of spontaneous intracranial hemorrhage

Yi-Wei Kao et al. Heliyon. .

Abstract

Background: -Spontaneous intracranial hemorrhage (ICH) has high fatality while has few proven treatments. We aim at investigating the association between dental scaling (DS) and the risk of ICH.

Methods: -In this cohort study, two cohorts were matched by propensity score based on potential confounders. Data from ICH between January 2008 and December 2014 in Taiwan were analyzed. The subjects underwent DS at least 6 times between January 1, 2002, and December 31, 2007, while the matched controls did not undergo any DS during the same period. Cumulative incidences and hazard ratios (HRs) were calculated after adjusting for competing confounders.

Results: -Each cohort consisted of 681,126 subjects. Compared with the non-DS cohort, the regular-DS cohort had a significantly lower incidence of ICH (0.8% vs 1.2%; P < 0.0001), and the adjusted hazards ratio (aHR) of 7-year ICH was 0.61 (95% confidence interval, CI, 0.59-0.63; P < 0.0001). The 30-39-year age group of the regular-DS cohort had the lowest HR (0.57; 95% CI, 0.52-0.61; P < 0.0001) of 7-year ICH when compared with similar controls. Compared with the controls, the regular-DS cohort also had significantly lower HR (0.82; 95% CI, 0.81-0.82; P < 0.0001) of 7-year hypertension. Compared with those without DS, the lowest risk of intracerebral hemorrhage was observed in the male participants with regular DS (0.43; 95% CI, 0.40-0.47; P < 0.0001).

Conclusions: -Regular DS was consistently associated with lower ICH risk in subjects aged 30-59 years, which may benefit from the decreased HBP risk. DS had a potential role in the prophylaxis for ICH, a condition with a high disability or mortality.

Keywords: Cohort study; Dental scaling; Hypertension; Intracranial hemorrhage.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flowchart of patient enrolment in the study. NHIRD, National Health Insurance Research Database; ICH, intracranial Hemorrhage; DS, dental scaling.
Fig. 2
Fig. 2
Kaplan–Meier Estimates of ICH-free survival at 6 years in the subjects with DS (case-cohort) or without DS (control cohort). The figure shows the probability of ICH at 6 years in subjects who underwent regular DS, as compared with those who did not. Panel A: the total case and control cohorts; Panel B: subjects aged 30–39 years; Panel C: subjects aged 40–49 years; Panel D: subjects aged 50–59 years. ICH, Intracranial Hemorrhage; DS, dental scaling.
Fig. 3
Fig. 3
Kaplan–Meier estimates of HTN-free survival at 6 years after the index date in the case and control cohorts without HTN. The probability of HTN at 6 years after the index date in subjects without HTN who underwent regular DS (case-cohort), as compared with those who did not undergo DS (control cohort). Panel A: total case and control cohorts; Panel B: subjects aged 30–39 years; Panel C: subjects aged 40–49 years; Panel D: subjects aged 50–59 years. HTN, hypertension; DS, dental scaling.

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