Corrigendum: Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis

Abstract

[This corrects the article DOI: 10.3389/fnins.2023.1106570.].

Keywords: Alzheimer's disease; auditory brainstem response; central auditory gain; central auditory processing disorder; hearing in noise; hearing loss; inhibitory deficit.

Figure 1

5xFAD transgenic mice have increased central gain and hearing loss severity. Auditory test results of (A–F) 5xFAD (red) at 12 months of age (12 M) (WT n = 13, 5xFAD n = 15), and (G–J) for APP/PS1 (magenta) at 13 M (WT n = 8, APP/PS1 n = 9). (A–J) Corresponding wild-type (WT) littermate data (black). (A) ABR and (B) DPOAE thresholds are expressed as the mean ± SEM. (C–J) Wave I (p1) amplitude, latency, wave IV to I amplitude ratio (p4:p1) and wave I to wave IV interpeak latency of click-evoked ABRs. Asterisks denote significant differences between genotypes: no significance (n.s.), p ≥ 0.05; *p < 0.05; **p < 0.01; and ***p < 0.001.

Figure 2

Auditory functions are normal in 5xFAD mice at an early stage of amyloid deposition. 5xFAD mice (red) and their WT littermates (black). (A) Wave I amplitude, latency, wave IV to I amplitude ratio, wave I to IV interpeak latency (from left to right) of click-evoked ABRs from 5xFAD mice (n = 14) and their WT littermates (n = 9) at 3 M. (B–E) Data are expressed as the mean ± SEM. (B) ABR (left) and DPOAE (right) thresholds from 5xFAD mice (n = 11) and their WT littermates (n = 7) at 3 M. (C) ABR threshold shift with masking and notched noise for 5xFAD mice (n = 10) and their WT littermates (n = 14) at 3 M. (D) ABR and (E) DPOAE threshold shifts at 1 day (1 DPN) and 14 days (14 DPN) post noise exposure for 5xFAD mice (n = 7) and their WT littermates (n = 4) at 3.5 M. No significance (n.s.).