Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct;130(10):1259-1267.
doi: 10.1007/s00702-023-02676-9. Epub 2023 Aug 3.

Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy

Sofia Cuoco  1 , Sara Ponticorvo  2 , Filomena Abate  1 , Maria Francesca Tepedino  1 , Roberto Erro  1 , Renzo Manara  3 , Gianfranco Di Salle  4 , Francesco Di Salle  1 , Maria Teresa Pellecchia  1 , Fabrizio Esposito  5 , Paolo Barone  1 , Marina Picillo  6
Affiliations

Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy

Sofia Cuoco et al. J Neural Transm (Vienna). 2023 Oct.

Abstract

Neuropsychiatric symptoms are intrinsic to Progressive Supranuclear Palsy (PSP) and a spoonful of studies investigated their imaging correlates. Describe (I) the frequency and severity of neuropsychiatric symptoms in PSP and (II) their structural imaging correlates. Twenty-six PSP patients underwent Neuropsychiatric Inventory (NPI) and brain 3D T1-weighted MRI. Spearman's rho with Bonferroni correction was used to investigate correlations between NPI scores and volumes of gray matter regions. More than 80% of patients presented at least one behavioral symptom of any severity. The most frequent and severe were depression/dysphoria, apathy, and irritability/lability. Significant relationships were found between the severity of irritability and right pars opercularis volume (p < 0.001) as well as between the frequency of agitation/aggression and left lateral occipital volume (p < 0.001). Depression, apathy, and irritability are the most common neuropsychiatric symptoms in PSP. Moreover, we found a relationship between specific positive symptoms as irritability and agitation/aggression and greater volume of the right pars opercularis cortex and lower volume of the left occipital cortex, respectively, which deserve further investigations.

Keywords: MRI; NPI; Neuropsychiatric symptoms; Progressive Supranuclear Palsy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest relevant to this work.

Figures

Fig. 1
Fig. 1
The distribution of symptoms according to disease duration
See this image and copyright information in PMC

References

    1. Aarsland D, Litvan I, Larsen JP. Neuropsychiatric symptoms of patients with progressive supranuclear palsy and Parkinson’s disease. J Neuropsychiatry Clin Neurosci. 2001;13:42–49. doi: 10.1176/jnp.13.1.42. - DOI - PubMed
    1. Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex: one decade on. Trends Cogn Sci. 2014;18(4):177–185. doi: 10.1016/j.tics.2013.12.003. - DOI - PubMed
    1. Baba H. Brain Nerve. 2018;70(9):961–970. doi: 10.11477/mf.1416201116. - DOI - PubMed
    1. Barber TR, Muhammed K, Drew D, et al. Apathy in rapid eye movement sleep behaviour disorder is common and under-recognized. Eur J Neurol. 2018;25(3):469–e32. doi: 10.1111/ene.13515. - DOI - PMC - PubMed
    1. Bertsch K, Grothe M, Prehn K, et al. Brain volumes differ between diagnostic groups of violent criminal offenders. Eur Arch Psychiatry Clin Neurosci. 2013;263(7):593–606. doi: 10.1007/s00406-013-0391-6. - DOI - PubMed

Publication types

MeSH terms