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Editorial
. 2023 Aug 4;133(4):350-352.
doi: 10.1161/CIRCRESAHA.123.323210. Epub 2023 Aug 3.

Mechanisms of Lymphatic Endothelial Cell Junction Transformations

Jianyong Zhong  1   2 , Elaine L Shelton  1 , Annet Kirabo  3   4 , Valentina Kon  1
Affiliations
Editorial

Mechanisms of Lymphatic Endothelial Cell Junction Transformations

Jianyong Zhong et al. Circ Res. .
No abstract available

Keywords: Editorials; endothelial cells; limpids; lymphatic vessels.

PubMed Disclaimer

Conflict of interest statement

Disclosures None.

Figures

Figure1.
Figure1.. Factors that promote transformation of lymphatic endothelial cell junctions.
This model outlines a mechanism by which lipids (chylomicrons) promote button junction formation in lacteals via upregulation of ROCK-mediated phosphorylation of myosin light chain (MLC) and subsequent cytoskeletal contraction. In contrast, zipper junctions are maintained via VEGF-A activation of VEGFR2/VEGFR3 heterodimers, which promotes PI3K/Akt-mediated Rac1 inhibition of cytoskeletal contraction. Junction plasticity in other lymphatic capillary beds can be influenced by several factors (infection, oxidative stress, glucocorticoids, biomechanical forces) and may play important roles in normal physiology and provide new therapeutic targets for conditions including fatty liver disease and respiratory infections.
See this image and copyright information in PMC

Comment on

  • Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption.
    Zarkada G, Chen X, Zhou X, Lange M, Zeng L, Lv W, Zhang X, Li Y, Zhou W, Liu K, Chen D, Ricard N, Liao J, Kim YB, Benedito R, Claesson-Welsh L, Alitalo K, Simons M, Ju R, Li X, Eichmann A, Zhang F. Zarkada G, et al. Circ Res. 2023 Aug 4;133(4):333-349. doi: 10.1161/CIRCRESAHA.123.322607. Epub 2023 Jul 18. Circ Res. 2023. PMID: 37462027 Free PMC article.

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