Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Aug 4;133(4):330-332.
doi: 10.1161/CIRCRESAHA.123.323281. Epub 2023 Aug 3.

Connecting the Dots From GWAS to Function in Atrial Fibrillation for ZFHX3

Sojin Y Wass  1 , Jonathan D Smith  1 , Mina K Chung  1
Affiliations
Editorial

Connecting the Dots From GWAS to Function in Atrial Fibrillation for ZFHX3

Sojin Y Wass et al. Circ Res. .
No abstract available

Keywords: Editorials; atrial fibrillation; genetics; genome-wide association study; risk.

PubMed Disclaimer

Conflict of interest statement

Disclosures None.

Figures

Figure.
Figure.. Connecting the dots between the AF GWAS locus on chromosome 16 and AF susceptibility.
Top. Some of the steps Jameson et al. used to identify the causal variant, rs12931021, which regulates ZFHX3 expression in iCMs. Top left Manhattan plot modified from Roselli, et al. Bottom. Identification of ZFHX3 as an AF susceptibility gene via the use of a tissue specific mouse knockout of Zfxh3.
See this image and copyright information in PMC

Comment on

References

    1. Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, Sigurdsson A, Jonasdottir A, Baker A, Thorleifsson G, Kristjansson K, et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature. 2007;448:353–7. - PubMed
    1. Benjamin EJ, Rice KM, Arking DE, Pfeufer A, van Noord C, Smith AV, Schnabel RB, Bis JC, Boerwinkle E, Sinner MF, et al. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet. 2009;41:879–81. - PMC - PubMed
    1. Roselli C, Chaffin M, Weng L, Aeschbacher S, Ahlberg G, Albert C, Almgren P, Alonso A, Anderson C, Aragam K, et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018;50:1225–1233. - PMC - PubMed
    1. Khera AV, Chaffin M, Aragam KG, Haas ME, Roselli C, Choi SH, Natarajan P, Lander ES, Lubitz SA, Ellinor P, et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018;50:1219–1224. - PMC - PubMed
    1. Choi SH, Jurgens SJ, Weng LC, Pirruccello JP, Roselli C, Chaffin M, Lee CJ, Hall AW, Khera AV, Lunetta KL, et al. Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank. Circ Res. 2020;126:200–209. - PMC - PubMed