doi: 10.1128/JVI.57.1.397-401.1986.
Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues
- PMID: 3753614
- PMCID: PMC252745
- DOI: 10.1128/JVI.57.1.397-401.1986
Item in Clipboard
Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues
J Virol.
1986 Jan.
Abstract
More than 600 monoclonal antiviral antibodies made against 11 different viruses were screened against 14 different organs from normal uninfected mice. Of these antiviral antibodies, 21, or approximately 3.5%, reacted with specific cells in these organs. Several of these antibodies were of the multiple-organ-reactive type and recognized antigens in more than one organ. It was concluded that the reactivity of monoclonal antiviral antibodies with normal tissues is a common phenomenon.
Similar articles
-
Preliminary serological characterization of bovine viral diarrhoea virus strains using monoclonal antibodies.Vet Microbiol. 1986 Sep;12(3):195-200. doi: 10.1016/0378-1135(86)90048-9. Vet Microbiol. 1986. PMID: 3022462
-
Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal antibodies cross-react with various self and non-self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies.Eur J Immunol. 1990 Nov;20(11):2383-7. doi: 10.1002/eji.1830201104. Eur J Immunol. 1990. PMID: 2253678
-
Development and characterization of neutralizing monoclonal antibodies against the pandemic H1N1 virus (2009).J Virol Methods. 2012 Jul;183(1):25-33. doi: 10.1016/j.jviromet.2012.03.016. Epub 2012 Apr 4. J Virol Methods. 2012. PMID: 22575685
-
[Preparation and characterization of monoclonal antibodies against M2 protein of avian influenza virus].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 May;24(5):475-8. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008. PMID: 18466706 Chinese.
-
Monoclonal IgM antibodies from cytomegalovirus-infected mice recognize the GlcNAc-containing receptor determinant of murine CMV as well as neutralizing anti-CMV IgG antibodies.Virology. 1992 May;188(1):143-51. doi: 10.1016/0042-6822(92)90743-9. Virology. 1992. PMID: 1373551
Cited by
-
Contemporary issues: diseases with a food vector.Clin Microbiol Rev. 1988 Oct;1(4):377-98. doi: 10.1128/CMR.1.4.377. Clin Microbiol Rev. 1988. PMID: 3069199 Free PMC article. Review.
-
Transgenic mouse lines that are immunologically tolerant and nontolerant to herpes simplex virus glycoprotein D.J Virol. 1991 Nov;65(11):6124-8. doi: 10.1128/JVI.65.11.6124-6128.1991. J Virol. 1991. PMID: 1717714 Free PMC article.
-
Systemic lupus erythematosus: RNA-protein autoantigens, models of disease heterogeneity, and theories of etiology.J Clin Immunol. 1991 Nov;11(6):297-316. doi: 10.1007/BF00918796. J Clin Immunol. 1991. PMID: 1722216 Review. No abstract available.
-
Diversity and origin of rheumatologic autoantibodies.Clin Microbiol Rev. 1991 Jul;4(3):256-69. doi: 10.1128/CMR.4.3.256. Clin Microbiol Rev. 1991. PMID: 1889043 Free PMC article. Review.
-
Sequence homology and immunologic cross-reactivity of human cytomegalovirus with HLA-DR beta chain: a means for graft rejection and immunosuppression.J Virol. 1988 Jan;62(1):100-5. doi: 10.1128/JVI.62.1.100-105.1988. J Virol. 1988. PMID: 2446012 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
