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. 1986 Jan;57(1):397-401.
doi: 10.1128/JVI.57.1.397-401.1986.

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues

J Srinivasappa, J Saegusa, B S Prabhakar, M K Gentry, M J Buchmeier, T J Wiktor, H Koprowski, M B Oldstone, A L Notkins

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues

J Srinivasappa et al. J Virol. 1986 Jan.

Abstract

More than 600 monoclonal antiviral antibodies made against 11 different viruses were screened against 14 different organs from normal uninfected mice. Of these antiviral antibodies, 21, or approximately 3.5%, reacted with specific cells in these organs. Several of these antibodies were of the multiple-organ-reactive type and recognized antigens in more than one organ. It was concluded that the reactivity of monoclonal antiviral antibodies with normal tissues is a common phenomenon.

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References

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