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. 2023 Sep;43(9):1152-1157.
doi: 10.1038/s41372-023-01728-y. Epub 2023 Aug 3.

Epidemiology, risk factors, and applicability of CDC definitions for healthcare-associated bloodstream infections at a level IV neonatal ICU

Anshu A Paul  1 , Eliza Gentzler  1 , Kyra Solowey  1   2 , Surya Manickam  1 , Irene Frantzis  1 , Luis Alba  1 , Maria Messina  3 , Sandhya S Brachio  1 , Lisa Saiman  4   5
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Epidemiology, risk factors, and applicability of CDC definitions for healthcare-associated bloodstream infections at a level IV neonatal ICU

Anshu A Paul et al. J Perinatol. 2023 Sep.

Abstract

Objectives: We studied the epidemiology of primary bloodstream infections (BSIs), secondary BSIs, and central line-associated BSIs (CLABSIs) and applicability of CDC definitions for primary sources of infection causing secondary BSIs in patients in the neonatal ICU.

Study design: We classified healthcare-associated BSIs (HABSIs) as primary BSIs, secondary BSIs, and CLABSIs using CDC surveillance definitions and determined their overall incidence and incidence among different gestational age strata. We assessed the applicability of CDC definitions for infection sources causing secondary BSIs.

Results: From 2010 to 2019, 141 (32.7%), 202 (46.9%), and 88 (20.4%) HABSIs were classified as primary BSIs, secondary BSIs, and CLABSIs, respectively; all declined during the study period (all p < 0.001). Gestational age <28 weeks was associated with increased incidence of all HABSI types. CDC criteria for site-specific primary sources were met in 137/202 (68%) secondary BSIs.

Conclusions: Primary and secondary BSIs were more common than CLABSIs and should be prioritized for prevention.

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References

    1. Brady MT. Health care–associated infections in the neonatal intensive care unit. Am J Infect Control. 2005;33:268–75. - DOI - PubMed - PMC
    1. Romanelli RMC, Anchieta LM, Mourão MVA, Campos FA, Loyola FC, Mourão PHO, et al. Risk factors and lethality of laboratory-confirmed bloodstream infection caused by non-skin contaminant pathogens in neonates. J Pediatr Versão Em Port. 2013;89:189–96.
    1. Sewell E, Roberts J, Mukhopadhyay S. Association of infection in neonates and long-term neurodevelopmental outcome. Clin Perinatol. 2021;48:251–61. - DOI - PubMed - PMC
    1. Pearlman SA. Quality improvement to reduce neonatal CLABSI: the journey to zero. Am J Perinatol. 2020;37:S14–7. - DOI - PubMed
    1. Balla KC, Rao SPN, Arul C, Shashidhar A, Prashantha YN, Nagaraj S, et al. Decreasing central line-associated bloodstream infections through quality improvement initiative. Indian Pediatr. 2018;55:753–6. - DOI - PubMed

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