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Meta-Analysis
. 2023 Sep;33(9):2917-2926.
doi: 10.1007/s11695-023-06747-4. Epub 2023 Aug 4.

Impact of Endoscopic Sleeve Gastroplasty in Non-alcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis

Beanie Conceição Medeiros Nunes  1 , Diogo Turiani Hourneaux de Moura  1 , Angelo So Taa Kum  1 , Guilherme Henrique Peixoto de Oliveira  1 , Bruno Salomão Hirsch  1 , Igor Braga Ribeiro  2 , Igor Logetto Caetité Gomes  1 , Claudia Pinto Marques de Oliveira  3 , Sultan Mahmood  4 , Wanderley Marques Bernardo  1 , Eduardo Guimarães Hourneaux de Moura  1
Affiliations
Meta-Analysis

Impact of Endoscopic Sleeve Gastroplasty in Non-alcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis

Beanie Conceição Medeiros Nunes et al. Obes Surg. 2023 Sep.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. Endoscopic sleeve gastroplasty (ESG) has proven to be feasible, safe, and effective in the management of obesity. We performed the first systematic review and meta-analysis evaluating NAFLD and other metabolic parameters 12 months post-ESG. Four observational studies with a total of 175 patients were included. The results showed a significant (p < 0.05) reduction of 4.85 in hepatic steatosis index (95% CI - 6.02, - 3.67), 0.5 in NAFLD fibrosis score (95% CI - 0.80, - 0.19), 6.32 U/l in ALT (95% CI - 9.52, - 3.11), 17.28% in TWL (95% CI - 18.24, - 16.31), 6.31 kg/m2 in BMI (95% CI - 8.11, - 4.52), 47.97% in EWL (95% CI - 49.10, - 46.84), and 0.51% in HbA1c (95% CI - 0.90, - 0.12). ESG improves liver parameters, provides weight loss, and reduces HbA1c levels in patients suffering from NAFLD.

Keywords: Bariatric; ESG; Endoscopic sleeve gastroplasty; Fatty liver disease; NAFLD; Obesity.

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