The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma

Abstract

To determine the predictive indexes of late cervical lymph node metastasis in early tongue squamous cell carcinoma (TSCC). We retrospectively analyzed the cases of 25 patients with stage I/II TSCC who had undergone surgical treatment without elective neck dissection. We evaluated the relationships between clinicopathologic factors and the occurrence of late cervical lymph node metastasis. Of the 25 cases, metastasis to the cervical lymph nodes was observed in nine cases (36.0%). The clinicopathological factors associated with late cervical lymph node metastasis were the mode of invasion (MOI, p = 0.032), depth of invasion (DOI, p = 0.004), and perineural invasion (PNI, p = 0.040). A multivariate analysis revealed that only the DOI was an independent predictor of late cervical lymph node metastasis. The combination of the DOI and MOI or the PNI and MOI was significantly correlated with late cervical lymph node metastasis (p = 0.004 and p = 0.012, respectively). Our findings suggest that combinations of the MOI, DOI, and PNI could be used as an index for predicting late cervical lymph node metastasis in early TSCC.

Keywords: Depth of invasion; Late cervical lymph node metastasis; Mode of invasion; Perineural invasion; Tongue squamous cell carcinoma.

Fig. 1

Kaplan–Meier estimates for 5-year cumulative survival based on late cervical lymph node metastasis. The 5-year cumulative survival rate of patients with late cervical lymph node metastasis (53.3%) was significantly lower than that of patients without it (100%) (p = 0.0043)