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Case Reports
. 2023 May 15;3(4):e242.
doi: 10.1002/ski2.242. eCollection 2023 Aug.

Sudden onset anhidrosis in an otherwise healthy male

Clara Michelle Tan Hwei Sian Tan  1 , Rayson Lee  2 , Janet Pei Ling Dua  3
Affiliations
Case Reports

Sudden onset anhidrosis in an otherwise healthy male

Clara Michelle Tan Hwei Sian Tan et al. Skin Health Dis. .

Abstract

Acquired idiopathic generalised anhidrosis (AIGA) is a rare disorder that is characterised by sudden onset generalised absence of sweating without any dermatological, neurological or sweat gland abnormalities. AIGA predominately affects young males, mostly involving patients of Asian descent. There have been approximately 100 reported cases worldwide, most of which were reported in Japan. In Singapore, it is rarely seen with one case series on 15 cases of AIGA reported in a 2014 study. Here, we present a case of AIGA who responded well to conservative management with sweating activity.

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Conflict of interest statement

None to declare.

Figures

FIGURE 1
FIGURE 1
Minor starch‐iodine sweat test: before exercising for 40 min.
FIGURE 2
FIGURE 2
Minor starch‐iodine sweat test: after exercising for 40 min.
FIGURE 3
FIGURE 3
Dark blue colouration over the dorsum of his (a & b) hands and palms and (c & d) axilla.
FIGURE 4
FIGURE 4
Patient's skin biopsy showing mild peri‐eccrine lymphocytic infiltrate with intact normal eccrine glands.
See this image and copyright information in PMC

References

    1. Khondker L, Sultana A. Generalized anhidrosis: a rare dermatological condition. Bangladesh Med J. 2014;41(3):57–8. 10.3329/bmj.v41i3.18962 - DOI
    1. Kageyama R, Honda T, Tokura Y. Acquired idiopathic generalized anhidrosis and its complications: implications for AIGA as an autoimmune disease. Int J Mol Sci. 2021;22(16):8389. 10.3390/ijms22168389 - DOI - PMC - PubMed
    1. Blandina P, Fantozzi R, Mannaioni PF, Masini E. Characteristics of histamine release evoked by acetylcholine in isolated rat mast cells. J Physiol. 1980;301(1):281–93. 10.1113/jphysiol.1980.sp013205 - DOI - PMC - PubMed
    1. Young AT, Yedidi RS, Raffi J, McCalmont TH, North J, Brinker A, et al. Idiopathic pure sudomotor failure: a review and two cases. Int J Womens Dermatol. 2020;7(3):276–9. 10.1016/j.ijwd.2020.12.011 - DOI - PMC - PubMed
    1. Chen CT, Lee DD. Idiopathic generalized anhidrosis with absence of sweat glands: a case report and literature review. Dermatol Sin. 2018;36(3):149–52. 10.1016/j.dsi.2018.01.001 - DOI

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