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Review
. 2023 May 26;15(3):349-359.
doi: 10.1016/j.chmed.2023.02.005. eCollection 2023 Jul.

Natto: A medicinal and edible food with health function

Chunfang Wang  1   2 , Jinpeng Chen  2   3   4 , Wenguo Tian  1   2 , Yanqi Han  2   3   4 , Xu Xu  2   3   4 , Tao Ren  2   3   4 , Chengwang Tian  2   3   4 , Changqing Chen  2   3   4
Affiliations
Review

Natto: A medicinal and edible food with health function

Chunfang Wang et al. Chin Herb Med. .

Abstract

Natto is a soybean product fermented by natto bacteria. It is rich in a variety of amino acids, vitamins, proteins and active enzymes. It has a number of biological activities, such as thrombolysis, prevention of osteoporosis, antibacterial, anticancer, antioxidant and so on. It is widely used in medicine, health-care food, biocatalysis and other fields. Natto is rich in many pharmacological active substances and has significant medicinal research value. This paper summarizes the pharmacological activities and applications of natto in and outside China, so as to provide references for further research and development of natto.

Keywords: active ingredients; application of natto; mechanisms of action; natto; pharmacological actions.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Thrombolysis mechanisms of nattokinase (NK). NK stimulates endothelial cells to produce t-PA and inhibits PAL-1 T-PA activates fibrinogen to form plasmin, which dissolves thrombus skeleton structure fibrin net, and releases platelets, and blood flow gradually returns to normal.
Fig. 2
Fig. 2
Antitumor process of natto extracts. NFDE and NWE could induce tumour cell autophagy at low concentrations (<3 μg/mL) or within a short time while the concentration increases to 5 μg/mL or after a moment, to be replaced by apoptosis. NFDE: natto freeze-drying extract; NEW: natto water extract; AMPK: AMP-activated protein kinase; ROS: reactive oxygen species.
Fig. 3
Fig. 3
Antihypertensive mechanism of natto extracts. Feeding CFB to SHRs can reduce blood pressure, including inhibiting plasma renin activity, reducing renal angiotensin II concentration, increasing whole blood coagulation time and reducing euglobulin clot dissolution time. SHRs: the spontaneously hypertensive rats; CFB: the culture filtrates from B. subtilis natto; SPB: systolic blood pressure; ECLA: the euglobulin clot lysis time.
Fig. 4
Fig. 4
Natto products in China.
See this image and copyright information in PMC

References

    1. Akbari S., Rasouli-Ghahroudi A.A. Vitamin K and bone metabolism: A review of the latest evidence in preclinical studies. BioMed Research International. 2018;2018 - PMC - PubMed
    1. An X.F., Liu H.R., Dai X.M., Zhang B. Effect of natto lipopeptide on human breast cancer mcf-7 cells. Science and Technology of Food Industry. 2014;35(3):343–350.
    1. Azimirad M., Alebouyeh M., Naji T. Inhibition of lipopolysaccharide-induced interleukin 8 in human adenocarcinoma cell line HT-29 by spore probiotics: B. coagulans and B. subtilis (natto). Probiotics and Antimicrobial. Proteins. 2017;9(1):56–63. - PubMed
    1. Bao K., Chen T.L., Zhang S., Huang Z.Z., Ding Q.Q. A succinyl isoflavone identified in natto promotes anti-ischemic effects in the middle cerebral artery occlusion rats. Journal of Functional Foods. 2020;73(2020)
    1. Bhat A.R., Irorere V.U., Bartlett T., Hill D., Kedia G., Morris M.R., et al. Bacillus subtilis natto: A non-toxic source of poly-γ-glutamic acid that could be used as a cryoprotectant for probiotic bacteria. AMB Express. 2013;3(1):36. - PMC - PubMed

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