doi: 10.1126/science.375393.
Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis
- PMID: 375393
- DOI: 10.1126/science.375393
Item in Clipboard
Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis
Science.
.
Abstract
Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.
Similar articles
-
Antigonadotropic actions of GnRH agonist on ovarian cells in vivo and in vitro.J Steroid Biochem. 1985 Nov;23(5B):765-70. doi: 10.1016/s0022-4731(85)80012-1. J Steroid Biochem. 1985. PMID: 3001418
-
Direct inhibitory effect of gonadotropin-releasing hormone upon luteal luteinizing hormone receptor and steroidogenesis in hypophysectomized rats.Endocrinology. 1980 Dec;107(6):1930-6. doi: 10.1210/endo-107-6-1930. Endocrinology. 1980. PMID: 6253282
-
Gonadotropin-releasing hormone analogs inhibit primate granulosa cell steroidogenesis via a mechanism distinct from that in the rat.Biol Reprod. 1990 Aug;43(2):305-11. doi: 10.1095/biolreprod43.2.305. Biol Reprod. 1990. PMID: 2165826
-
Regulation of ovarian granulosa and luteal cell functions by gonadotropin releasing hormone and its antagonist.Adv Exp Med Biol. 1982;147:223-62. doi: 10.1007/978-1-4615-9278-5_14. Adv Exp Med Biol. 1982. PMID: 6295082 Review. No abstract available.
-
Direct effects of gonadotropin releasing hormone on testicular Leydig cell functions.Ann N Y Acad Sci. 1982;383:249-71. doi: 10.1111/j.1749-6632.1982.tb23172.x. Ann N Y Acad Sci. 1982. PMID: 6283993 Review. No abstract available.
Cited by
-
Effect of chronic treatment with [D-Ala6, des-Gly-NH210]LHRH ethylamide on ovarian histology in the rat.Cell Tissue Res. 1982;227(1):213-9. doi: 10.1007/BF00206342. Cell Tissue Res. 1982. PMID: 6756639
-
Analogues of gonadotrophin releasing hormone.Br Med J (Clin Res Ed). 1984 Feb 11;288(6415):426-7. doi: 10.1136/bmj.288.6415.426. Br Med J (Clin Res Ed). 1984. PMID: 6419950 Free PMC article. No abstract available.
-
Sex differences in primary hypertension.Biol Sex Differ. 2012 Mar 14;3(1):7. doi: 10.1186/2042-6410-3-7. Biol Sex Differ. 2012. PMID: 22417477 Free PMC article.
-
Similar luteinizing hormone-releasing hormone binding sites in rat anterior pituitary and ovary.Proc Natl Acad Sci U S A. 1980 Sep;77(9):5567-71. doi: 10.1073/pnas.77.9.5567. Proc Natl Acad Sci U S A. 1980. PMID: 6254091 Free PMC article.
-
Histrelin. A review of its pharmacological properties and therapeutic role in central precocious puberty.Drugs. 1993 Apr;45(4):570-88. doi: 10.2165/00003495-199345040-00008. Drugs. 1993. PMID: 7684676 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
