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. 1979 May 25;204(4395):854-5.
doi: 10.1126/science.375393.

Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis

A J Hsueh, G F Erickson

Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis

A J Hsueh et al. Science. .

Abstract

Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.

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