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Multicenter Study
. 2023 May 28;48(5):760-770.
doi: 10.11817/j.issn.1672-7347.2023.220629.

Advances of perioperative acute kidney injury in elderly patients undergoing non-cardiac surgery

[Article in English, Chinese]
Zhaohua Pang  1   2 , Wangyuan Zou  3   4
Affiliations
Multicenter Study

Advances of perioperative acute kidney injury in elderly patients undergoing non-cardiac surgery

[Article in English, Chinese]
Zhaohua Pang et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. .

Abstract
in English, Chinese

The risk of developing perioperative acute kidney injury (AKI) in elderly patients increases with age. The combined involvement of aging kidneys, coexisting multiple underlying chronic diseases, and increased exposure to potential renal stressors and nephrotoxic drugs or invasive procedures constitute susceptibility factors for AKI in elderly patients. The perioperative AKI in elderly patients undergoing noncardiac surgery has its own specific population characteristics, so it is necessary to further explore the characteristics of AKI in elderly patients in terms of epidemiology, clinical diagnosis, risk factors, and preventive and curative measures to provide meaningful clinical advice to improve prognosis, accelerate recovery, and reduce medical burden in elderly patients. Since AKI has the fastest-growing incidence in older patients and is associated with a worse prognosis, early detection, early diagnosis, and prevention of AKI are important for elderly patients in the perioperative period. Large, multicenter, randomized controlled clinical studies in elderly non-cardiac surgery patients with AKI can be conducted in the future, with the aim of providing the evidence to reduce of the incidence of AKI and to improve the prognosis of patients.

老年患者围手术期急性肾损伤(acute kidney injury，AKI)的发病风险随年龄的增长而不断增加。衰老的肾、并存多种慢性基础疾病以及暴露于潜在的肾应激源和肾毒素的药物或侵入性操作的机会增加共同构成了老年患者AKI的易感因素。老年患者非心脏手术围手术期AKI有其特殊的人群特征，因此有必要针对老年患者AKI在流行病学、临床诊断、危险因素和防治措施等方面的特点进行进一步的探讨，以提供有意义的临床意见来指导改善老年患者预后、加速疾病康复和减少医疗负担。由于AKI在老年患者中的发病率增长最快，并且与更差的预后相关；因此，早期发现、早期诊断和防治AKI对于围手术期的老年患者非常重要。未来有待在非心脏手术的老年AKI患者中开展大样本、多中心、随机对照的临床研究，以期为降低患者AKI的发生率和改善预后提供循证医学证据。.

Keywords: acute kidney injury; elderly; non-cardiac surgery; peri-operation; prevention; susceptibility; treatment.

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Conflict of interest statement

作者声称无任何利益冲突。

Figures

图1
图1
老年患者AKI的易感因素 Figure 1 Susceptibility factors of AKI in elderly patients
图2
图2
老年患者非心脏手术围手术期AKI研究进展 Figure 2 Progress in perioperative AKI studies in elderly patients undergoing non-cardiac surgery AKI: Acute kidney injury; CRRT: Continuous renal replacement therapy.
See this image and copyright information in PMC

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