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. 1986 Mar;320(6058):134-9.
doi: 10.1038/320134a0.

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

S Green, P Walter, V Kumar, A Krust, J M Bornert, P Argos, P Chambon

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

S Green et al. Nature. 1986 Mar.

Abstract

We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.

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