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Review
. 2023 Nov 1;35(6):317-323.
doi: 10.1097/BOR.0000000000000961. Epub 2023 Aug 3.

Targeting B cells for treatment of systemic sclerosis

Hitoshi Terui  1 , Yuichiro Segawa, Yoshihide Asano
Affiliations
Review

Targeting B cells for treatment of systemic sclerosis

Hitoshi Terui et al. Curr Opin Rheumatol. .

Abstract

Purpose of review: The pathogenesis of systemic sclerosis (SSc) has been linked to dysfunctional B cells as demonstrated in previous research. This review aims to show the evidence and ongoing clinical trials of B cell-targeted therapy and overview the various aspects of B cell involvement in SSc.

Recent findings: We provide an overview of the current understanding and therapeutic strategies targeting B cells in SSc patients. Several molecular targets of B cells have been identified for treating SSc, including CD20, CD19, B-cell activating factor (BAFF), and proteasome.

Summary: Many clinical trials have demonstrated that B cells play a critical role in the pathogenesis of SSc and may be a potential therapeutic target to improve disease symptoms. Although large-scale clinical studies are needed, various B cell-targeted therapies have the potential to address the unmet needs of SSc patients.

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References

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