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Comment
. 2023 Aug 3;186(16):3329-3331.
doi: 10.1016/j.cell.2023.07.005.

Unveiling TMEM106B: SARS-CoV-2's secret entrance to the cell

Alexander Lacrampe  1 , Fenghua Hu  2
Affiliations
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Comment

Unveiling TMEM106B: SARS-CoV-2's secret entrance to the cell

Alexander Lacrampe et al. Cell. .
Free article

Abstract

The lysosomal membrane protein TMEM106B functions as a proviral factor in SARS-CoV-2 infection, though it was not known how. In this issue of Cell, Baggen et al. demonstrate that TMEM106B serves as an ACE2-independent receptor for SARS-CoV-2 entry by promoting the fusion of the viral membrane with the lysosomal membrane.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.
    Baggen J, Jacquemyn M, Persoons L, Vanstreels E, Pye VE, Wrobel AG, Calvaresi V, Martin SR, Roustan C, Cronin NB, Reading E, Thibaut HJ, Vercruysse T, Maes P, De Smet F, Yee A, Nivitchanyong T, Roell M, Franco-Hernandez N, Rhinn H, Mamchak AA, Ah Young-Chapon M, Brown E, Cherepanov P, Daelemans D. Baggen J, et al. Cell. 2023 Aug 3;186(16):3427-3442.e22. doi: 10.1016/j.cell.2023.06.005. Epub 2023 Jul 7. Cell. 2023. PMID: 37421949 Free PMC article.

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