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Comment
. 2023 Aug 3;30(8):1001-1003.
doi: 10.1016/j.stem.2023.07.005.

Replacing microglia to treat Alzheimer's disease

Peng Jiang  1 , Mengmeng Jin  2
Affiliations
Comment

Replacing microglia to treat Alzheimer's disease

Peng Jiang et al. Cell Stem Cell. .

Abstract

In this issue of Cell Stem Cell, Yoo et al.1 report that replacing Trem2 knockout microglia with Trem2 wild-type microglia-like cells derived from systemically transplanted hematopoietic cells rectifies microglial dysfunction in a mouse model of amyloidosis. These findings highlight the potential of microglia replacement therapy for Alzheimer's disease treatment.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. Microglia replacement therapy for treating AD
(A) Yoo et al. demonstrate that the replacement of Trem2-deficient microglia with Trem2 wild-type microglia-like cells via systemic transplantation of mouse hematopoietic cells restores microglial dysfunction in an Aβ mouse model. (B) Potential future research questions may include identifying the optimal cell type for microglia replacement, selecting suitable rodent models to validate microglia replacement therapy, and conducting comprehensive functional and mechanistic analyses of microglia replacement therapy.
See this image and copyright information in PMC

Comment on

References

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