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Comment
. 2023 Aug 3;83(15):2621-2623.
doi: 10.1016/j.molcel.2023.07.005.

NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation

Elliott M Bernard  1 , Petr Broz  2
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Comment

NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation

Elliott M Bernard et al. Mol Cell. .
Free article

Abstract

Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al.1 implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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